MeDALL (Mechanizmy powstawania alergii): Zintegrowane podejście - od fenotypów do medycyny systemowej

Translated title of the contribution: MeDALL (Mechanisms of the Development of ALLergy): An integrated approach from phenotypes to systems medicine

Marek L. Kowalski, Mubeccel Akdis, Charles Auffray, Thomas Keil, Josep Anto, Jean Bousquet, I. Grupa Badawcza Medall, T. Haahtela, A. Cambon-Thomsen, B. N. Lambrecht, D. S. Postma, J. Sunyer, R. Valenta, C. A. Akdis, I. Annesi-Maesano, A. Arno, C. Bachert, F. Ballester, X. Basagana, U. BaumgartnerC. Bindslev-Jensen, B. Brunekreef, K. H. Carlsen, L. Chatzi, R. Crameri, E. Eveno, F. Forastiere, J. Garcia-Aymerich, S. Guerra, H. Hammad, J. Heinrich, D. Hirsch, B. Jacquemin, F. Kauffmann, M. Kerkhof, M. Kogevinas, G. H. Koppelman, S. Lau, K. C. Lodrup-Carlsen, M. Lopez-Botet, J. Lotvall, C. Lupinek, D. Maier, M. J. Makela, F. D. Martinez, J. Mestres, I. Momas, M. C. Nawijn, A. Neubauer, S. Oddie, S. Palkonen, I. Pin, C. Pison, F. Rancé, S. Reitamo, E. Rial-Sebbag, M. Salapatas, V. Siroux, D. Smagghe, M. Torrent, E. Toskala, P. Van Cauwenberge, A. J.M. Van Oosterhout, R. Varraso, L. Von Hertzen, M. Wickman, C. Wijmenga, M. Worm, J. Wright, T. Zuberbier

Research output: Contribution to journalArticle

Abstract

The origin of the epidemic of IgE-associated (allergic) diseases is unclear. MeDALL (Mechanisms of the Development of ALLergy), an FP7 European Union project (No. 264357), aims to generate novel knowledge on the mechanisms of initiation of allergy and to propose early diagnosis, prevention, and targets for therapy. A novel phenotype definition and an integrative translational approach are needed to understand how a network of molecular and environmental factors can lead to complex allergic diseases. A novel, stepwise, large-scale, and integrative approach will be led by a network of complementary experts in allergy, epidemiology, allergen biochemistry, immunology, molecular biology, epigenetics, functional genomics, bioinformatics, computational and systems biology. The following steps are proposed: (i) Identification of 'classical' and 'novel' phenotypes in existing birth cohorts; (ii) Building discovery of the relevant mechanisms in IgE-associated allergic diseases in existing longitudinal birth cohorts and Karelian children; (iii) Validation and redefinition of classical and novel phenotypes of IgE-associated allergic diseases; and (iv) Translational integration of systems biology outcomes into health care, including societal aspects. MeDALL will lead to: (i) A better understanding of allergic phenotypes, thus expanding current knowledge of the genomic and environmental determinants of allergic diseases in an integrative way; (ii) Novel diagnostic tools for the early diagnosis of allergy, targets for the development of novel treatment modalities, and prevention of allergic diseases; (iii) Improving the health of European citizens as well as increasing the competitiveness and boosting the innovative capacity of Europe, while addressing global health issues and ethical issues.

Translated title of the contributionMeDALL (Mechanisms of the Development of ALLergy): An integrated approach from phenotypes to systems medicine
Original languagePolish
Pages (from-to)3-11
Number of pages9
JournalAlergia Astma Immunologia
Volume16
Issue number1
StatePublished - Mar 2011

Keywords

  • Allergy
  • Early diagnosis
  • Epigenetics
  • Framework programme 7
  • IgE
  • MeDALL
  • Mechanisms
  • Prevention
  • Proteomics
  • Systems medicine
  • Transcriptomics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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  • Cite this

    Kowalski, M. L., Akdis, M., Auffray, C., Keil, T., Anto, J., Bousquet, J., Grupa Badawcza Medall, I., Haahtela, T., Cambon-Thomsen, A., Lambrecht, B. N., Postma, D. S., Sunyer, J., Valenta, R., Akdis, C. A., Annesi-Maesano, I., Arno, A., Bachert, C., Ballester, F., Basagana, X., ... Zuberbier, T. (2011). MeDALL (Mechanizmy powstawania alergii): Zintegrowane podejście - od fenotypów do medycyny systemowej. Alergia Astma Immunologia, 16(1), 3-11.