Mediation of spinal nerve injury induced tactile allodynia by descending facilitatory pathways in the dorsolateral funiculus in rats

Michael H. Ossipov, Hong Sun T., Phil Malan, Josephine Lai, Frank Porreca

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Evidence exists to indicate that tactile allodynia arising from peripheral nerve injury is integrated predominately at supraspinal, rather than spinal, sites. In the present experiments, the possibility that disruption of descending pathways through the dorsolateral funiculus (DLF) might alter expression of nerve-injury induced tactile allodynia was explored. Male, Sprague-Dawley rats received L5/L6 spinal nerve ligation (SNL). Lesions to the DLF were made ipsilateral or contralateral to SNL. Tactile allodynia was determined by measuring withdrawal thresholds to probing with von Frey filaments. Rats with DLF lesions presented no apparent motor deficits and did not alter sensory threshold in sham-SNL operated rats. DLF lesions made ipsilateral to SNL completely blocked tactile allodynia in SNL rats. Contralateral DLF lesions and sham surgery did not have any effect on SNL-induced allodynia. These results indicate that tactile allodynia after peripheral nerve injury is dependent upon tonic activation of net descending facilitation from supraspinal sites and support the hypothesis of tonic activation of descending facilitation as a basis for chronic pain. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalNeuroscience Letters
Volume290
Issue number2
DOIs
StatePublished - Aug 25 2000

Fingerprint

Spinal Injuries
Spinal Nerves
Hyperalgesia
Ligation
Peripheral Nerve Injuries
Sensory Thresholds
Chronic Pain
Sprague Dawley Rats
Wounds and Injuries

Keywords

  • Descending modulation
  • Dorsolateral funiculus lesion
  • Facilitation
  • Neuropathic pain
  • Tactile allodynia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mediation of spinal nerve injury induced tactile allodynia by descending facilitatory pathways in the dorsolateral funiculus in rats. / Ossipov, Michael H.; T., Hong Sun; Malan, Phil; Lai, Josephine; Porreca, Frank.

In: Neuroscience Letters, Vol. 290, No. 2, 25.08.2000, p. 129-132.

Research output: Contribution to journalArticle

Ossipov, Michael H. ; T., Hong Sun ; Malan, Phil ; Lai, Josephine ; Porreca, Frank. / Mediation of spinal nerve injury induced tactile allodynia by descending facilitatory pathways in the dorsolateral funiculus in rats. In: Neuroscience Letters. 2000 ; Vol. 290, No. 2. pp. 129-132.
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