Mediators and moderators in early intervention research

Nicholas Jk Breitborde, Vinod H. Srihari, Jessica M. Pollard, Donald N. Addington, Scott W. Woods

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Aim: The goal of this paper is to provide clarification with regard to the nature of mediator and moderator variables and the statistical methods used to test for the existence of these variables. Particular attention will be devoted to discussing the ways in which the identification of mediator and moderator variables may help to advance the field of early intervention in psychiatry. Methods: We completed a literature review of the methodological strategies used to test for mediator and moderator variables. Results: Although several tests for mediator variables are currently available, recent evaluations suggest that tests which directly evaluate the indirect effect are superior. With regard to moderator variables, two approaches ('pick-a-point' and regions of significance) are available, and we provide guidelines with regard to how researchers can determine which approach may be most appropriate to use for their specific study. Finally, we discuss how to evaluate the clinical importance of mediator and moderator relationships as well as the methodology to calculate statistical power for tests of mediation and moderation. Conclusion: Further exploration of mediator and moderator variables may provide valuable information with regard to interventions provided early in the course of a psychiatric illness.

Original languageEnglish (US)
Pages (from-to)143-152
Number of pages10
JournalEarly Intervention in Psychiatry
Volume4
Issue number2
DOIs
StatePublished - 2010

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Epidemiologic Effect Modifiers
Research
Psychiatry
Research Personnel
Guidelines

Keywords

  • Early intervention
  • Mediators
  • Methodology
  • Moderators
  • Statistics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Phychiatric Mental Health
  • Biological Psychiatry
  • Medicine(all)

Cite this

Mediators and moderators in early intervention research. / Breitborde, Nicholas Jk; Srihari, Vinod H.; Pollard, Jessica M.; Addington, Donald N.; Woods, Scott W.

In: Early Intervention in Psychiatry, Vol. 4, No. 2, 2010, p. 143-152.

Research output: Contribution to journalArticle

Breitborde, Nicholas Jk ; Srihari, Vinod H. ; Pollard, Jessica M. ; Addington, Donald N. ; Woods, Scott W. / Mediators and moderators in early intervention research. In: Early Intervention in Psychiatry. 2010 ; Vol. 4, No. 2. pp. 143-152.
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