Melanin concentrating hormone (MCH): The message sequence

Ana Maria de L. Castrucci, Michal Lebl, Victor J. Hruby, Terry O. Matsunaga, Mac E. Hadley

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melanocytes. We have synthesized a number of MCH analogues to determine the essential features of the primary structure necessary to stimulate either melanosome aggregation or dispersion in fish or tetrapod melanocytes, respectively. An analysis of the potencies and actions of these analogues on vertebrate melanocytes is provided and demonstrates that the two activities have different structural requirements.

Original languageEnglish (US)
Pages (from-to)1141-1148
Number of pages8
JournalLife Sciences
Volume45
Issue number13
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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