Melanophore stimulating hormone

Release inhibition by ring structures of neurohypophysial hormones

Victor J Hruby, Clark W. Smith, Sister Annette Bower, Mac E. Hadley

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Tocinamide and tocinoic acid, ring structures of oxytocin, are potent inhibitors of the release of melanophore stimulating hormone from the rat and hamster pituitary in vitro. Tocinamide is effective at concentrations as low as 10-14M on the mammalian pituitary. These peptides do not affect release of the hormone on the frog (Rana pipiens) pars intermedia, but they do inhibit release in the bullfrog (Rana catesbeiana) and the toad (Bufo marinus). The specificity of the peptides on inhibition of the hormone is demonstrated by the fact that oxytocin, lysine vasopressin, and pressinoic acid and pressinamide (ring structures of the vasopressins) do not show such inhibitory activity. Hypothalamic extracts of either the frog (Rana pipiens) or the rat inhibit release of the hormone from pituitaries of either species. The inhibitory effects of tocinamide and tocinoic acid, like that of hypothalamic extracts, are reversible.

Original languageEnglish (US)
Pages (from-to)1331-1332
Number of pages2
JournalScience
Volume176
Issue number4041
StatePublished - 1972

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Posterior Pituitary Hormones
Melanocyte-Stimulating Hormones
Anura
Rana pipiens
Rana catesbeiana
Oxytocin
Lypressin
Bufo marinus
Hormones
Peptides
Pituitary Hormones
Vasopressins
Cricetinae
tocinamide
tocinoic acid

ASJC Scopus subject areas

  • General

Cite this

Hruby, V. J., Smith, C. W., Bower, S. A., & Hadley, M. E. (1972). Melanophore stimulating hormone: Release inhibition by ring structures of neurohypophysial hormones. Science, 176(4041), 1331-1332.

Melanophore stimulating hormone : Release inhibition by ring structures of neurohypophysial hormones. / Hruby, Victor J; Smith, Clark W.; Bower, Sister Annette; Hadley, Mac E.

In: Science, Vol. 176, No. 4041, 1972, p. 1331-1332.

Research output: Contribution to journalArticle

Hruby, VJ, Smith, CW, Bower, SA & Hadley, ME 1972, 'Melanophore stimulating hormone: Release inhibition by ring structures of neurohypophysial hormones', Science, vol. 176, no. 4041, pp. 1331-1332.
Hruby, Victor J ; Smith, Clark W. ; Bower, Sister Annette ; Hadley, Mac E. / Melanophore stimulating hormone : Release inhibition by ring structures of neurohypophysial hormones. In: Science. 1972 ; Vol. 176, No. 4041. pp. 1331-1332.
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