Melatonin induced increase in gamma-interferon production by murine splenocytes

Lucas Luis Colombo, Guan Jie Chen, Maria C. Lopez, Ronald R Watson

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Previously, we demonstrated that production of gamma-interferon (γ-IFN) by the mouse splenocytes isolated at night was higher than from those isolated in the morning. In this paper we show that melatonin increased γ-IFN production by murine splenocytes. Moreover, this stimulating effect was significantly higher (10 times) in the cells isolated at night than in those isolated in the morning (2 times).

Original languageEnglish (US)
Pages (from-to)123-126
Number of pages4
JournalImmunology Letters
Volume33
Issue number2
DOIs
StatePublished - 1992

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Melatonin
Interferon-gamma

Keywords

  • Circadian rhythm
  • Melatonin
  • Pineal
  • γ-IFN

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Melatonin induced increase in gamma-interferon production by murine splenocytes. / Colombo, Lucas Luis; Chen, Guan Jie; Lopez, Maria C.; Watson, Ronald R.

In: Immunology Letters, Vol. 33, No. 2, 1992, p. 123-126.

Research output: Contribution to journalArticle

Colombo, Lucas Luis ; Chen, Guan Jie ; Lopez, Maria C. ; Watson, Ronald R. / Melatonin induced increase in gamma-interferon production by murine splenocytes. In: Immunology Letters. 1992 ; Vol. 33, No. 2. pp. 123-126.
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