Melatonin induced increase in gamma-interferon production by murine splenocytes

Lucas Luis Colombo, Guan Jie Chen, Maria C. Lopez, Ronald Ross Watson

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Previously, we demonstrated that production of gamma-interferon (γ-IFN) by the mouse splenocytes isolated at night was higher than from those isolated in the morning. In this paper we show that melatonin increased γ-IFN production by murine splenocytes. Moreover, this stimulating effect was significantly higher (10 times) in the cells isolated at night than in those isolated in the morning (2 times).

Original languageEnglish (US)
Pages (from-to)123-126
Number of pages4
JournalImmunology Letters
Volume33
Issue number2
DOIs
StatePublished - Jul 1992

Keywords

  • Circadian rhythm
  • Melatonin
  • Pineal
  • γ-IFN

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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