Memory deficits characterized by patterns of lesions to the hippocampus and parahippocampal cortex

Véronique D. Bohbot, John J.B. Allen, Lynn Nadel

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

Spatial and nonspatial memory tests were given to patients with small thermal lesions administered to the medial temporal lobes in an attempt at alleviating pharmacologically resistant epilepsy. In all three spatial memory experiments presented in this paper, patients with lesions that included the right parahippocampal cortex were seriously impaired. Their impairment, together with the performance of patients with lesions to the right hippocampus (sparing the right parahippocampal cortex), provides the different patterns of deficits that lead to different interpretations of the function of the parahippocampal cortex. The distinction between the effects of functional damage in hippocampus and the effects of a lesion to the hippocampus or to regions surrounding the hippocampus, such as the parahippocampal cortex, is emphasized. We conclude that the right parahippocampal cortex participates in spatial memory beyond serving as a gateway to the hippocampus.

Original languageEnglish (US)
Pages (from-to)355-368
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume911
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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