Meniscus body position, size, and shape in persons with and persons without radiographic knee osteoarthritis: Quantitative analyses of knee magnetic resonance images from the osteoarthritis initiative

Andrea Wenger, Wolfgang Wirth, Martin Hudelmaier, Iris Noebauer-Huhmann, Siegfried Trattnig, Katja Bloecker, Richard B. Frobell, Chian K Kwoh, Felix Eckstein, Martin Englund

Research output: Contribution to journalArticle

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Abstract

Objective To quantitatively evaluate the position, size, and shape of the menisci in subjects with radiographic knee osteoarthritis (OA) compared to subjects without OA, using magnetic resonance imaging (MRI). Methods We studied the right knees of 39 Osteoarthritis Initiative participants (24 women and 15 men with a mean age of 59.6 ± 8.7 years) with medial compartment radiographic tibiofemoral OA (Kellgren/Lawrence grade of 2 or 3). Subjects were matched individually for age, sex, and height to controls without knee OA and without risk factors for knee OA. The right knees of the controls were used as references. One observer performed manual segmentation of the tibial plateau and the medial and lateral meniscus based on a coronally reconstructed double-echo steady-state sequence with water excitation, focusing on 5 central 3T MRIs. Results In OA knees, there was less meniscal coverage of the medial tibial plateau (435 mm2 versus 515 mm2; P = 0.0004), the medial meniscus body showed more extrusion (2.64 mm versus 0.53 mm; P < 0.0001), and the peripheral margin had a more convex shape, i.e., bulged more (mean 0.61 mm versus 0.27 mm; P < 0.0001). The thickness or volume of the medial meniscus body of OA knees did not differ substantially from reference knees. In contrast, in OA knees the lateral meniscus body had a larger volume (mean 266 mm 3 versus 224 mm3; P = 0.0005) and extruded more (mean 1.16 mm versus -1.01 mm; P < 0.0001), and the external margin bulged more (mean 0.53 mm versus 0.35 mm; P < 0.0001), than in reference knees. Conclusion Our findings indicate altered meniscal position and shape (i.e., more bulging) in both compartments in medial compartment knee OA. These changes may be important features of OA pathogenesis and/or disease consequences.

Original languageEnglish (US)
Pages (from-to)1804-1811
Number of pages8
JournalArthritis and Rheumatism
Volume65
Issue number7
DOIs
StatePublished - Jul 2013
Externally publishedYes

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Knee Osteoarthritis
Body Size
Osteoarthritis
Tibial Meniscus
Knee
Magnetic Resonance Spectroscopy
Meniscus
Magnetic Resonance Imaging
Water

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Rheumatology
  • Pharmacology (medical)

Cite this

Meniscus body position, size, and shape in persons with and persons without radiographic knee osteoarthritis : Quantitative analyses of knee magnetic resonance images from the osteoarthritis initiative. / Wenger, Andrea; Wirth, Wolfgang; Hudelmaier, Martin; Noebauer-Huhmann, Iris; Trattnig, Siegfried; Bloecker, Katja; Frobell, Richard B.; Kwoh, Chian K; Eckstein, Felix; Englund, Martin.

In: Arthritis and Rheumatism, Vol. 65, No. 7, 07.2013, p. 1804-1811.

Research output: Contribution to journalArticle

Wenger, Andrea ; Wirth, Wolfgang ; Hudelmaier, Martin ; Noebauer-Huhmann, Iris ; Trattnig, Siegfried ; Bloecker, Katja ; Frobell, Richard B. ; Kwoh, Chian K ; Eckstein, Felix ; Englund, Martin. / Meniscus body position, size, and shape in persons with and persons without radiographic knee osteoarthritis : Quantitative analyses of knee magnetic resonance images from the osteoarthritis initiative. In: Arthritis and Rheumatism. 2013 ; Vol. 65, No. 7. pp. 1804-1811.
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abstract = "Objective To quantitatively evaluate the position, size, and shape of the menisci in subjects with radiographic knee osteoarthritis (OA) compared to subjects without OA, using magnetic resonance imaging (MRI). Methods We studied the right knees of 39 Osteoarthritis Initiative participants (24 women and 15 men with a mean age of 59.6 ± 8.7 years) with medial compartment radiographic tibiofemoral OA (Kellgren/Lawrence grade of 2 or 3). Subjects were matched individually for age, sex, and height to controls without knee OA and without risk factors for knee OA. The right knees of the controls were used as references. One observer performed manual segmentation of the tibial plateau and the medial and lateral meniscus based on a coronally reconstructed double-echo steady-state sequence with water excitation, focusing on 5 central 3T MRIs. Results In OA knees, there was less meniscal coverage of the medial tibial plateau (435 mm2 versus 515 mm2; P = 0.0004), the medial meniscus body showed more extrusion (2.64 mm versus 0.53 mm; P < 0.0001), and the peripheral margin had a more convex shape, i.e., bulged more (mean 0.61 mm versus 0.27 mm; P < 0.0001). The thickness or volume of the medial meniscus body of OA knees did not differ substantially from reference knees. In contrast, in OA knees the lateral meniscus body had a larger volume (mean 266 mm 3 versus 224 mm3; P = 0.0005) and extruded more (mean 1.16 mm versus -1.01 mm; P < 0.0001), and the external margin bulged more (mean 0.53 mm versus 0.35 mm; P < 0.0001), than in reference knees. Conclusion Our findings indicate altered meniscal position and shape (i.e., more bulging) in both compartments in medial compartment knee OA. These changes may be important features of OA pathogenesis and/or disease consequences.",
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T1 - Meniscus body position, size, and shape in persons with and persons without radiographic knee osteoarthritis

T2 - Quantitative analyses of knee magnetic resonance images from the osteoarthritis initiative

AU - Wenger, Andrea

AU - Wirth, Wolfgang

AU - Hudelmaier, Martin

AU - Noebauer-Huhmann, Iris

AU - Trattnig, Siegfried

AU - Bloecker, Katja

AU - Frobell, Richard B.

AU - Kwoh, Chian K

AU - Eckstein, Felix

AU - Englund, Martin

PY - 2013/7

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N2 - Objective To quantitatively evaluate the position, size, and shape of the menisci in subjects with radiographic knee osteoarthritis (OA) compared to subjects without OA, using magnetic resonance imaging (MRI). Methods We studied the right knees of 39 Osteoarthritis Initiative participants (24 women and 15 men with a mean age of 59.6 ± 8.7 years) with medial compartment radiographic tibiofemoral OA (Kellgren/Lawrence grade of 2 or 3). Subjects were matched individually for age, sex, and height to controls without knee OA and without risk factors for knee OA. The right knees of the controls were used as references. One observer performed manual segmentation of the tibial plateau and the medial and lateral meniscus based on a coronally reconstructed double-echo steady-state sequence with water excitation, focusing on 5 central 3T MRIs. Results In OA knees, there was less meniscal coverage of the medial tibial plateau (435 mm2 versus 515 mm2; P = 0.0004), the medial meniscus body showed more extrusion (2.64 mm versus 0.53 mm; P < 0.0001), and the peripheral margin had a more convex shape, i.e., bulged more (mean 0.61 mm versus 0.27 mm; P < 0.0001). The thickness or volume of the medial meniscus body of OA knees did not differ substantially from reference knees. In contrast, in OA knees the lateral meniscus body had a larger volume (mean 266 mm 3 versus 224 mm3; P = 0.0005) and extruded more (mean 1.16 mm versus -1.01 mm; P < 0.0001), and the external margin bulged more (mean 0.53 mm versus 0.35 mm; P < 0.0001), than in reference knees. Conclusion Our findings indicate altered meniscal position and shape (i.e., more bulging) in both compartments in medial compartment knee OA. These changes may be important features of OA pathogenesis and/or disease consequences.

AB - Objective To quantitatively evaluate the position, size, and shape of the menisci in subjects with radiographic knee osteoarthritis (OA) compared to subjects without OA, using magnetic resonance imaging (MRI). Methods We studied the right knees of 39 Osteoarthritis Initiative participants (24 women and 15 men with a mean age of 59.6 ± 8.7 years) with medial compartment radiographic tibiofemoral OA (Kellgren/Lawrence grade of 2 or 3). Subjects were matched individually for age, sex, and height to controls without knee OA and without risk factors for knee OA. The right knees of the controls were used as references. One observer performed manual segmentation of the tibial plateau and the medial and lateral meniscus based on a coronally reconstructed double-echo steady-state sequence with water excitation, focusing on 5 central 3T MRIs. Results In OA knees, there was less meniscal coverage of the medial tibial plateau (435 mm2 versus 515 mm2; P = 0.0004), the medial meniscus body showed more extrusion (2.64 mm versus 0.53 mm; P < 0.0001), and the peripheral margin had a more convex shape, i.e., bulged more (mean 0.61 mm versus 0.27 mm; P < 0.0001). The thickness or volume of the medial meniscus body of OA knees did not differ substantially from reference knees. In contrast, in OA knees the lateral meniscus body had a larger volume (mean 266 mm 3 versus 224 mm3; P = 0.0005) and extruded more (mean 1.16 mm versus -1.01 mm; P < 0.0001), and the external margin bulged more (mean 0.53 mm versus 0.35 mm; P < 0.0001), than in reference knees. Conclusion Our findings indicate altered meniscal position and shape (i.e., more bulging) in both compartments in medial compartment knee OA. These changes may be important features of OA pathogenesis and/or disease consequences.

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