Merging Visible Light with Cross-Coupling: The Photochemical Direct C-H Difluoroalkylation of Imidazopyridines

Chuan Hua Qu, Gui Ting Song, Jia Xu, Wei Yan, Cheng He Zhou, Hong Yu Li, Zhong Zhu Chen, Zhi Gang Xu

Research output: Contribution to journalArticle

Abstract

A transition-metal-free protocol for the difluoroalkylation of imidazopyridines with bromodifluoroaryl ketones promoted by visible light irradiation is presented. This protocol is distinguished by simple, mild, and catalyst-free reaction conditions with a wide reaction scope, which is complementary to existing difluoroalkylation strategies by photoredox scenarios. Additionally, this protocol potentially offers a new way for streamlining the synthesis of compounds containing the difluoro moiety.

Original languageEnglish (US)
JournalOrganic Letters
DOIs
StateAccepted/In press - Jan 1 2019

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cross coupling
Ketones
Merging
Transition metals
streamlining
Metals
Irradiation
Light
Catalysts
ketones
transition metals
catalysts
irradiation
synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Merging Visible Light with Cross-Coupling : The Photochemical Direct C-H Difluoroalkylation of Imidazopyridines. / Qu, Chuan Hua; Song, Gui Ting; Xu, Jia; Yan, Wei; Zhou, Cheng He; Li, Hong Yu; Chen, Zhong Zhu; Xu, Zhi Gang.

In: Organic Letters, 01.01.2019.

Research output: Contribution to journalArticle

Qu, Chuan Hua ; Song, Gui Ting ; Xu, Jia ; Yan, Wei ; Zhou, Cheng He ; Li, Hong Yu ; Chen, Zhong Zhu ; Xu, Zhi Gang. / Merging Visible Light with Cross-Coupling : The Photochemical Direct C-H Difluoroalkylation of Imidazopyridines. In: Organic Letters. 2019.
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