Meridional development of the infant crystalline lens

John D Twelker, S. K. Kirschbaum, K. Zadnik, D. O. Mutti

Research output: Contribution to journalArticle

Abstract

Purpose. We previously presented biometric data from infants 4 to 15 months of age (ARVO, 1994). We are continuing our investigation of ocular growth and refractive development by examining two meridians of the crystalline lens in older infants. Methods. We evaluated the right eye of 11 subjects ranging from 9 to 29 months under cycloplegia (cyclopentolate 1% after proparacaine 0.5%). We assessed refractive error by retinoscopy, axial dimensions by A-scan ultrasonography, and corneal radius, crystalline lens radius, and crystalline lens power using a video-based keratophakometer which records Purkinje images I, III, and IV in two orthogonal meridians. Results. In the horizontal meridian, the mean anterior crystalline lens radius was 9.10 ± 0.79mm and the mean posterior radius was 4.79 ± 0.37mm. In the vertical meridian, the mean anterior crystalline lens radius was 9.35 ± 0.88mm and the mean posterior radius was 5.03 ± 0.38mm. The posterior crystalline lens radius in the horizontal meridian flattened with age (radius=3.98+0.05(age (months)), r=0.73, p=0.03) while the anterior crystalline lens radius was not quite statistically significant for age-related flattening (radius=7.57+0.09(age (months)), r=0.64, p=0.06). There were no statistically significant age-related trends in the anterior and posterior crystalline lens radius in the vertical meridian (anterior: r=0.52, p=0.10; posterior: r=0.16, p=0.64). Conclusions. In contrast to previous pilot data in infants from 4 to 15 months, which showed no age-related changes in crystalline lens radius, our data from older infants and toddlers show flatter crystalline lens radii in the horizontal posterior meridian with increasing age. The flattening of the horizontal posterior crystalline lens radius, while the other crystalline lens radii stayed the same, may contribute to a shift toward with-the-rule astigmatism. These cross-sectional trends require confirmation by longitudinal studies.

Original languageEnglish (US)
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
StatePublished - Feb 15 1996
Externally publishedYes

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Crystalline Lens
Child Development
Meridians
Cyclopentolate
Retinoscopy
Refractive Errors
Astigmatism
Growth and Development
Longitudinal Studies
Ultrasonography

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Meridional development of the infant crystalline lens. / Twelker, John D; Kirschbaum, S. K.; Zadnik, K.; Mutti, D. O.

In: Investigative Ophthalmology and Visual Science, Vol. 37, No. 3, 15.02.1996.

Research output: Contribution to journalArticle

Twelker, John D ; Kirschbaum, S. K. ; Zadnik, K. ; Mutti, D. O. / Meridional development of the infant crystalline lens. In: Investigative Ophthalmology and Visual Science. 1996 ; Vol. 37, No. 3.
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title = "Meridional development of the infant crystalline lens",
abstract = "Purpose. We previously presented biometric data from infants 4 to 15 months of age (ARVO, 1994). We are continuing our investigation of ocular growth and refractive development by examining two meridians of the crystalline lens in older infants. Methods. We evaluated the right eye of 11 subjects ranging from 9 to 29 months under cycloplegia (cyclopentolate 1{\%} after proparacaine 0.5{\%}). We assessed refractive error by retinoscopy, axial dimensions by A-scan ultrasonography, and corneal radius, crystalline lens radius, and crystalline lens power using a video-based keratophakometer which records Purkinje images I, III, and IV in two orthogonal meridians. Results. In the horizontal meridian, the mean anterior crystalline lens radius was 9.10 ± 0.79mm and the mean posterior radius was 4.79 ± 0.37mm. In the vertical meridian, the mean anterior crystalline lens radius was 9.35 ± 0.88mm and the mean posterior radius was 5.03 ± 0.38mm. The posterior crystalline lens radius in the horizontal meridian flattened with age (radius=3.98+0.05(age (months)), r=0.73, p=0.03) while the anterior crystalline lens radius was not quite statistically significant for age-related flattening (radius=7.57+0.09(age (months)), r=0.64, p=0.06). There were no statistically significant age-related trends in the anterior and posterior crystalline lens radius in the vertical meridian (anterior: r=0.52, p=0.10; posterior: r=0.16, p=0.64). Conclusions. In contrast to previous pilot data in infants from 4 to 15 months, which showed no age-related changes in crystalline lens radius, our data from older infants and toddlers show flatter crystalline lens radii in the horizontal posterior meridian with increasing age. The flattening of the horizontal posterior crystalline lens radius, while the other crystalline lens radii stayed the same, may contribute to a shift toward with-the-rule astigmatism. These cross-sectional trends require confirmation by longitudinal studies.",
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N2 - Purpose. We previously presented biometric data from infants 4 to 15 months of age (ARVO, 1994). We are continuing our investigation of ocular growth and refractive development by examining two meridians of the crystalline lens in older infants. Methods. We evaluated the right eye of 11 subjects ranging from 9 to 29 months under cycloplegia (cyclopentolate 1% after proparacaine 0.5%). We assessed refractive error by retinoscopy, axial dimensions by A-scan ultrasonography, and corneal radius, crystalline lens radius, and crystalline lens power using a video-based keratophakometer which records Purkinje images I, III, and IV in two orthogonal meridians. Results. In the horizontal meridian, the mean anterior crystalline lens radius was 9.10 ± 0.79mm and the mean posterior radius was 4.79 ± 0.37mm. In the vertical meridian, the mean anterior crystalline lens radius was 9.35 ± 0.88mm and the mean posterior radius was 5.03 ± 0.38mm. The posterior crystalline lens radius in the horizontal meridian flattened with age (radius=3.98+0.05(age (months)), r=0.73, p=0.03) while the anterior crystalline lens radius was not quite statistically significant for age-related flattening (radius=7.57+0.09(age (months)), r=0.64, p=0.06). There were no statistically significant age-related trends in the anterior and posterior crystalline lens radius in the vertical meridian (anterior: r=0.52, p=0.10; posterior: r=0.16, p=0.64). Conclusions. In contrast to previous pilot data in infants from 4 to 15 months, which showed no age-related changes in crystalline lens radius, our data from older infants and toddlers show flatter crystalline lens radii in the horizontal posterior meridian with increasing age. The flattening of the horizontal posterior crystalline lens radius, while the other crystalline lens radii stayed the same, may contribute to a shift toward with-the-rule astigmatism. These cross-sectional trends require confirmation by longitudinal studies.

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