Mesoscopic-scale functional networks in the primate Amygdala

Jeremiah K. Morrow, Michael X. Cohen, Katalin M. Gothard

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The primate amygdala performs multiple functions that may be related to the anatomical heterogeneity of its nuclei. Individual neurons with stimulus-and task-specific responses are not clustered in any of the nuclei, suggesting that single-units may be too-fine grained to shed light on the mesoscale organization of the amygdala. We have extracted from local field potentials recorded simultaneously from multiple locations within the primate (Macaca mulatta) amygdala spatially defined and statistically separable responses to visual, tactile, and auditory stimuli. A generalized eigendecomposition-based method of source separation isolated coactivity patterns, or components, that in neurophysiological terms correspond to putative subnetworks. Some component spatial patterns mapped onto the anatomical organization of the amygdala, while other components reflected integration across nuclei. These components differentiated between visual, tactile, and auditory stimuli suggesting the presence of functionally distinct parallel subnetworks.

Original languageEnglish (US)
Article numbere57341
Pages (from-to)1-21
Number of pages21
JournaleLife
Volume9
DOIs
StatePublished - Sep 2020

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'Mesoscopic-scale functional networks in the primate Amygdala'. Together they form a unique fingerprint.

Cite this