MET receptor tyrosine kinase as an autism genetic risk factor

Yun Peng, Matthew Huentelman, Christopher Smith, Shenfeng Qiu

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Scopus citations

Abstract

In this chapter, we will briefly discuss recent literature on the role of MET receptor tyrosine kinase (RTK) in brain development and how perturbation of MET signaling may alter normal neurodevelopmental outcomes. Recent human genetic studies have established MET as a risk factor for autism, and the molecular and cellular underpinnings of this genetic risk are only beginning to emerge from obscurity. Unlike many autism risk genes that encode synaptic proteins, the spatial and temporal expression pattern of MET RTK indicates this signaling system is ideally situated to regulate neuronal growth, functional maturation, and establishment of functional brain circuits, particularly in those brain structures involved in higher levels of cognition, social skills, and executive functions.

Original languageEnglish (US)
Title of host publicationInternational Review of Neurobiology
PublisherAcademic Press Inc.
Pages135-165
Number of pages31
DOIs
StatePublished - 2013

Publication series

NameInternational Review of Neurobiology
Volume113
ISSN (Print)0074-7742

Keywords

  • Autism spectrum disorder
  • Brain circuits
  • Hepatocyte growth factor
  • MET receptor tyrosine kinase
  • Neurodevelopment
  • Risk gene
  • Synaptic connectivity

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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  • Cite this

    Peng, Y., Huentelman, M., Smith, C., & Qiu, S. (2013). MET receptor tyrosine kinase as an autism genetic risk factor. In International Review of Neurobiology (pp. 135-165). (International Review of Neurobiology; Vol. 113). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-418700-9.00005-8