Meta-analysis: Quantitative integration of independent research results

T. R. Einarson, W. F. McGhan, J Lyle Bootman, D. L. Sabers

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Meta-analysis, a quantitative method of combining the results of independent research studies, is described as a method for reviewing research literature. Four steps are taken to summarize the research in an area. First, a thorough literature review is conducted to identify a group of research studies with the relevant treatment variable. Second, an effect size is calculated for each study. Third, an overall (composite) effect size is determined by a weighted combination of the obtained effect sizes. Fourth, a fail-safe N (the number of unpublished studies with opposing conclusions needed to negate the published literature) is calculated to assess the certainty of the overall effect size. Meta-analysis was applied to 33 studies of chymopapain in an illustrative example. The analysis produced a large effect size of 0.8082 and a fail-safe N of 214, indicating strong support for the effectiveness of the treatment with chymopapain. Meta-analysis can be a useful tool if it is used properly. It is particularly useful as an adjunct to other methods of review that are used in pharmacy practice.

Original languageEnglish (US)
Pages (from-to)1957-1964
Number of pages8
JournalAmerican Journal of Hospital Pharmacy
Volume42
Issue number9
StatePublished - 1985

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Meta-Analysis
Chymopapain
Research

ASJC Scopus subject areas

  • Leadership and Management
  • Pharmaceutical Science

Cite this

Meta-analysis : Quantitative integration of independent research results. / Einarson, T. R.; McGhan, W. F.; Bootman, J Lyle; Sabers, D. L.

In: American Journal of Hospital Pharmacy, Vol. 42, No. 9, 1985, p. 1957-1964.

Research output: Contribution to journalArticle

Einarson, T. R. ; McGhan, W. F. ; Bootman, J Lyle ; Sabers, D. L. / Meta-analysis : Quantitative integration of independent research results. In: American Journal of Hospital Pharmacy. 1985 ; Vol. 42, No. 9. pp. 1957-1964.
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