Metabolic interplay between gut bacteria and their host

Frank Duca, Philippe Gérard, Mihai Covasa, Patricia Lepage

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

Shifts in the bacterial composition of the human gut microbiota (i.e. dysbiosis) have been associated with digestive tract dysfunctions such as inflammatory bowel diseases. More strikingly, strong evidence, from both human studies and germ-free animal models, links intestinal microbiota dysbiosis with metabolic disorders, such as obesity and liver diseases. This chapter focuses on the changes and impact of the gut microbiota during these diseased states, and describes the possible direct and indirect mechanisms that an aberrant gut microbiota can promote metabolic dysregulations. The possible involvement of the 'microbiota-gut-brain' axis in the development of obesity is further discussed, as is the perspective of meta-omic technologies that give insight into the functions and potential effect of the non-cultured intestinal bacteria on the host health. Understanding how modifications in this finely tuned ecosystem lead to these pathological processes is crucial for the development of new therapeutic approaches to treat and hopefully ameliorate these metabolic diseases.

Original languageEnglish (US)
Title of host publicationHow Gut and Brain Control Metabolism
PublisherS. Karger AG
Pages73-82
Number of pages10
Volume42
ISBN (Electronic)9783318026399
ISBN (Print)9783318026382
DOIs
StatePublished - Apr 10 2014
Externally publishedYes

Fingerprint

Bacteria
Dysbiosis
Obesity
Metabolic Diseases
Pathologic Processes
Inflammatory Bowel Diseases
Ecosystem
Gastrointestinal Tract
Liver Diseases
Animal Models
Gastrointestinal Microbiome
Technology
Health
Brain
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Duca, F., Gérard, P., Covasa, M., & Lepage, P. (2014). Metabolic interplay between gut bacteria and their host. In How Gut and Brain Control Metabolism (Vol. 42, pp. 73-82). S. Karger AG. https://doi.org/10.1159/000358315

Metabolic interplay between gut bacteria and their host. / Duca, Frank; Gérard, Philippe; Covasa, Mihai; Lepage, Patricia.

How Gut and Brain Control Metabolism. Vol. 42 S. Karger AG, 2014. p. 73-82.

Research output: Chapter in Book/Report/Conference proceedingChapter

Duca, F, Gérard, P, Covasa, M & Lepage, P 2014, Metabolic interplay between gut bacteria and their host. in How Gut and Brain Control Metabolism. vol. 42, S. Karger AG, pp. 73-82. https://doi.org/10.1159/000358315
Duca F, Gérard P, Covasa M, Lepage P. Metabolic interplay between gut bacteria and their host. In How Gut and Brain Control Metabolism. Vol. 42. S. Karger AG. 2014. p. 73-82 https://doi.org/10.1159/000358315
Duca, Frank ; Gérard, Philippe ; Covasa, Mihai ; Lepage, Patricia. / Metabolic interplay between gut bacteria and their host. How Gut and Brain Control Metabolism. Vol. 42 S. Karger AG, 2014. pp. 73-82
@inbook{0329cd90ea454a67afb5bd2814aa0631,
title = "Metabolic interplay between gut bacteria and their host",
abstract = "Shifts in the bacterial composition of the human gut microbiota (i.e. dysbiosis) have been associated with digestive tract dysfunctions such as inflammatory bowel diseases. More strikingly, strong evidence, from both human studies and germ-free animal models, links intestinal microbiota dysbiosis with metabolic disorders, such as obesity and liver diseases. This chapter focuses on the changes and impact of the gut microbiota during these diseased states, and describes the possible direct and indirect mechanisms that an aberrant gut microbiota can promote metabolic dysregulations. The possible involvement of the 'microbiota-gut-brain' axis in the development of obesity is further discussed, as is the perspective of meta-omic technologies that give insight into the functions and potential effect of the non-cultured intestinal bacteria on the host health. Understanding how modifications in this finely tuned ecosystem lead to these pathological processes is crucial for the development of new therapeutic approaches to treat and hopefully ameliorate these metabolic diseases.",
author = "Frank Duca and Philippe G{\'e}rard and Mihai Covasa and Patricia Lepage",
year = "2014",
month = "4",
day = "10",
doi = "10.1159/000358315",
language = "English (US)",
isbn = "9783318026382",
volume = "42",
pages = "73--82",
booktitle = "How Gut and Brain Control Metabolism",
publisher = "S. Karger AG",

}

TY - CHAP

T1 - Metabolic interplay between gut bacteria and their host

AU - Duca, Frank

AU - Gérard, Philippe

AU - Covasa, Mihai

AU - Lepage, Patricia

PY - 2014/4/10

Y1 - 2014/4/10

N2 - Shifts in the bacterial composition of the human gut microbiota (i.e. dysbiosis) have been associated with digestive tract dysfunctions such as inflammatory bowel diseases. More strikingly, strong evidence, from both human studies and germ-free animal models, links intestinal microbiota dysbiosis with metabolic disorders, such as obesity and liver diseases. This chapter focuses on the changes and impact of the gut microbiota during these diseased states, and describes the possible direct and indirect mechanisms that an aberrant gut microbiota can promote metabolic dysregulations. The possible involvement of the 'microbiota-gut-brain' axis in the development of obesity is further discussed, as is the perspective of meta-omic technologies that give insight into the functions and potential effect of the non-cultured intestinal bacteria on the host health. Understanding how modifications in this finely tuned ecosystem lead to these pathological processes is crucial for the development of new therapeutic approaches to treat and hopefully ameliorate these metabolic diseases.

AB - Shifts in the bacterial composition of the human gut microbiota (i.e. dysbiosis) have been associated with digestive tract dysfunctions such as inflammatory bowel diseases. More strikingly, strong evidence, from both human studies and germ-free animal models, links intestinal microbiota dysbiosis with metabolic disorders, such as obesity and liver diseases. This chapter focuses on the changes and impact of the gut microbiota during these diseased states, and describes the possible direct and indirect mechanisms that an aberrant gut microbiota can promote metabolic dysregulations. The possible involvement of the 'microbiota-gut-brain' axis in the development of obesity is further discussed, as is the perspective of meta-omic technologies that give insight into the functions and potential effect of the non-cultured intestinal bacteria on the host health. Understanding how modifications in this finely tuned ecosystem lead to these pathological processes is crucial for the development of new therapeutic approaches to treat and hopefully ameliorate these metabolic diseases.

UR - http://www.scopus.com/inward/record.url?scp=84925865946&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925865946&partnerID=8YFLogxK

U2 - 10.1159/000358315

DO - 10.1159/000358315

M3 - Chapter

C2 - 24732926

AN - SCOPUS:84903826960

SN - 9783318026382

VL - 42

SP - 73

EP - 82

BT - How Gut and Brain Control Metabolism

PB - S. Karger AG

ER -