Metabolism and rate of elimination of digoxigenin bisdigitoxoside in dogs before and during chronic azotemia

K. D. Gierke, P. E. Graves, D. Perrier, F. I. Marcus, Michael Mayersohn, Steven Goldman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the metabolism and rate of elimination of digoxigenin bisdigitoxoside (bis) before and during chronic azotemia in dogs. Bis was eliminated primarily by nonrenal mechanisms. The half-life of bis was 18.5 hr, compared to 31.6 hr for digoxin, and was not significantly increased in azotemic dogs. The oral bioavailability of bis in azotemic dogs relative to an intravenous dose was approximately 46%.

Original languageEnglish (US)
Pages (from-to)448-451
Number of pages4
JournalJournal of Pharmacology and Experimental Therapeutics
Volume212
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Azotemia
Dogs
Digoxin
Biological Availability
Half-Life
digoxigenin-bis(digitoxoside)

ASJC Scopus subject areas

  • Pharmacology

Cite this

Metabolism and rate of elimination of digoxigenin bisdigitoxoside in dogs before and during chronic azotemia. / Gierke, K. D.; Graves, P. E.; Perrier, D.; Marcus, F. I.; Mayersohn, Michael; Goldman, Steven.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 212, No. 3, 1980, p. 448-451.

Research output: Contribution to journalArticle

@article{79bd28e5437d479393ab36a1f0b60eff,
title = "Metabolism and rate of elimination of digoxigenin bisdigitoxoside in dogs before and during chronic azotemia",
abstract = "The purpose of this study was to evaluate the metabolism and rate of elimination of digoxigenin bisdigitoxoside (bis) before and during chronic azotemia in dogs. Bis was eliminated primarily by nonrenal mechanisms. The half-life of bis was 18.5 hr, compared to 31.6 hr for digoxin, and was not significantly increased in azotemic dogs. The oral bioavailability of bis in azotemic dogs relative to an intravenous dose was approximately 46{\%}.",
author = "Gierke, {K. D.} and Graves, {P. E.} and D. Perrier and Marcus, {F. I.} and Michael Mayersohn and Steven Goldman",
year = "1980",
language = "English (US)",
volume = "212",
pages = "448--451",
journal = "Journal of Pharmacology and Experimental Therapeutics",
issn = "0022-3565",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "3",

}

TY - JOUR

T1 - Metabolism and rate of elimination of digoxigenin bisdigitoxoside in dogs before and during chronic azotemia

AU - Gierke, K. D.

AU - Graves, P. E.

AU - Perrier, D.

AU - Marcus, F. I.

AU - Mayersohn, Michael

AU - Goldman, Steven

PY - 1980

Y1 - 1980

N2 - The purpose of this study was to evaluate the metabolism and rate of elimination of digoxigenin bisdigitoxoside (bis) before and during chronic azotemia in dogs. Bis was eliminated primarily by nonrenal mechanisms. The half-life of bis was 18.5 hr, compared to 31.6 hr for digoxin, and was not significantly increased in azotemic dogs. The oral bioavailability of bis in azotemic dogs relative to an intravenous dose was approximately 46%.

AB - The purpose of this study was to evaluate the metabolism and rate of elimination of digoxigenin bisdigitoxoside (bis) before and during chronic azotemia in dogs. Bis was eliminated primarily by nonrenal mechanisms. The half-life of bis was 18.5 hr, compared to 31.6 hr for digoxin, and was not significantly increased in azotemic dogs. The oral bioavailability of bis in azotemic dogs relative to an intravenous dose was approximately 46%.

UR - http://www.scopus.com/inward/record.url?scp=0018935499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018935499&partnerID=8YFLogxK

M3 - Article

C2 - 7359346

AN - SCOPUS:0018935499

VL - 212

SP - 448

EP - 451

JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

SN - 0022-3565

IS - 3

ER -