Metabolism of Hexachlorophene in the Rabbit. Excretion, Tissue Distribution, and Characterization of the Urinary Glucuronide Conjugate

A. Jay Gandolfi, Donald R. Buhler

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Rabbits were given intraperitoneal doses of 10 or 15 mg/kg [ 14C]hexachlorophene. About 48-52% of the administered radioactivity was excreted in the feces and 21-25% in the urine over a 3.5-4-day period. Unchanged hexachlorophene (HCP) was a major constituent of feces (78%) and urine (29%) of rabbits receiving a 15 mg/kg dose of [14C]HCP. The major urinary metabolite (56%), HCP glucuronide, was isolated and characterized.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Volume25
Issue number1
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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