Methamphetamine in heart disease

Thomas S. Eagan, Ronald R Watson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The rise in abuse of methamphetamine is a serious concern today. This paper explores possible connections between methamphetamine abuse and heart disease. Methamphetamine's increase of catecholamine levels causes an acute increase in cardiac stress, tone, and platelet aggregation. This may lead to vascular occlusion, rupture of coronary lesions, vasoconstriction, infarction, or dilated cardiomyopathy. Hypertension and tachycardia might promote aneurysms or aortic dissection. In experimental situations, methamphetamine causes myocardial hypertrophy, atrophy, cellular disarray, edema, eosinophilic degeneration, cellular infiltration, myolysis, granulation tissue, and fibrosis. Upon cessation of methamphetamine use, most of these conditions will reverse with time. However, fibrosis will not reverse itself. Methamphetamine also damages microtubular and actin cellular structures with prolonged use. Noncardiac complications are briefly discussed. This paper also includes a review of amphetamine and 3,4-methyl-enedioxymethamphetamine ("ecstasy"), noting that they have similar effects on the heart. Diagnosis and treatment are also described. More research is needed to evaluate the many potential actions that methamphetamine has on the heart.

Original languageEnglish (US)
Pages (from-to)320-324
Number of pages5
JournalCardiovascular Reviews and Reports
Volume23
Issue number6
StatePublished - 2002

Fingerprint

Methamphetamine
Heart Diseases
Fibrosis
Granulation Tissue
Aortic Aneurysm
Coronary Occlusion
Dilated Cardiomyopathy
Cellular Structures
Vasoconstriction
Platelet Aggregation
Tachycardia
Infarction
Hypertrophy
Action Potentials
Atrophy
Catecholamines
Blood Vessels
Dissection
Actins
Rupture

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Methamphetamine in heart disease. / Eagan, Thomas S.; Watson, Ronald R.

In: Cardiovascular Reviews and Reports, Vol. 23, No. 6, 2002, p. 320-324.

Research output: Contribution to journalArticle

Eagan, Thomas S. ; Watson, Ronald R. / Methamphetamine in heart disease. In: Cardiovascular Reviews and Reports. 2002 ; Vol. 23, No. 6. pp. 320-324.
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