TY - GEN

T1 - Method of calibrating response statistics for ML estimation of 3D interaction position in a thick-detector gamma camera

AU - Hunter, William C.J.

AU - Barrett, Harrison H.

AU - Furenlid, Lars R.

AU - Moore, Stephen K.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - High-energy photon detectors are often made thick in order to improve their photon-detection efficiency. To avoid issues of parallax and increased signal variance that result from random interaction depth, we must determine the 3D interaction position in the imaging detector. With this goal in mind, we examine a method of calibrating response statistics of a thick-detector gamma camera to produce a maximum- likelihood estimate of 3D interaction position. We parameterize the mean detector response as a function of 3D position and estimate the parameters by maximizing their likelihood given prior knowledge of the pathlength distribution and a complete list of camera signals for an ensemble of gamma-ray interactions. Demonstrating this calibration method with simulated gamma-camera data, we show that the resulting calibration is accurate and can be used to produce unbiased estimates of 3D interaction position.

AB - High-energy photon detectors are often made thick in order to improve their photon-detection efficiency. To avoid issues of parallax and increased signal variance that result from random interaction depth, we must determine the 3D interaction position in the imaging detector. With this goal in mind, we examine a method of calibrating response statistics of a thick-detector gamma camera to produce a maximum- likelihood estimate of 3D interaction position. We parameterize the mean detector response as a function of 3D position and estimate the parameters by maximizing their likelihood given prior knowledge of the pathlength distribution and a complete list of camera signals for an ensemble of gamma-ray interactions. Demonstrating this calibration method with simulated gamma-camera data, we show that the resulting calibration is accurate and can be used to produce unbiased estimates of 3D interaction position.

UR - http://www.scopus.com/inward/record.url?scp=48149095235&partnerID=8YFLogxK

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U2 - 10.1109/NSSMIC.2007.4437079

DO - 10.1109/NSSMIC.2007.4437079

M3 - Conference contribution

AN - SCOPUS:48149095235

SN - 1424409233

SN - 9781424409235

T3 - IEEE Nuclear Science Symposium Conference Record

SP - 4359

EP - 4363

BT - 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC

T2 - 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC

Y2 - 27 October 2007 through 3 November 2007

ER -