MGEA5-14 polymorphism and type 2 diabetes in Mexico City

E. A. Cameron, V. L. Martinez-Marignac, A. Chan, A. Valladares, L. V. Simmonds, N. Wacher, J. Kumate, P. McKeigue, M. D. Shriver, R. Kittles, M. Cruz, Esteban J. Parra

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A family-based study has recently reported that a variant located in intron 10 of the gene MGEA5 increases susceptibility to Type 2 Diabetes (T2D). We evaluated the distribution of this SNP in a sample of T2D patients (N = 271) and controls (N = 244) from Mexico City. The frequency of the T allele was higher in the cases (2.6%) than in the controls (1.8%). After adjusting for age, sex, BMI, education, and individual ancestry the odds ratio was 1.60 but the 95% confidence interval was wide and overlapped 1 (0.52-4.86, P-value: 0.404). In order to characterize the distribution of the MGEA5-14 polymorphism in the relevant parental populations, we genotyped this variant in European (and European Americans), West African, and Native American samples. The T-allele was present at a frequency of 2.3% in Spain, 4.2% in European Americans, and 13% in Western Africans, but was absent in two Native American samples from Mexico and Peru. Given the low frequency of the T-allele, further studies using large sample sizes will be required to confirm the role of this variant in T2D.

Original languageEnglish (US)
Pages (from-to)593-596
Number of pages4
JournalAmerican Journal of Human Biology
Volume19
Issue number4
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy
  • Ecology, Evolution, Behavior and Systematics
  • Anthropology
  • Genetics

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    Cameron, E. A., Martinez-Marignac, V. L., Chan, A., Valladares, A., Simmonds, L. V., Wacher, N., Kumate, J., McKeigue, P., Shriver, M. D., Kittles, R., Cruz, M., & Parra, E. J. (2007). MGEA5-14 polymorphism and type 2 diabetes in Mexico City. American Journal of Human Biology, 19(4), 593-596. https://doi.org/10.1002/ajhb.20639