MGEA5-14 polymorphism and type 2 diabetes in Mexico City

E. A. Cameron, V. L. Martinez-Marignac, A. Chan, A. Valladares, L. V. Simmonds, N. Wacher, J. Kumate, P. McKeigue, M. D. Shriver, Rick A Kittles, M. Cruz, Esteban J. Parra

Research output: Contribution to journalArticle

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Abstract

A family-based study has recently reported that a variant located in intron 10 of the gene MGEA5 increases susceptibility to Type 2 Diabetes (T2D). We evaluated the distribution of this SNP in a sample of T2D patients (N = 271) and controls (N = 244) from Mexico City. The frequency of the T allele was higher in the cases (2.6%) than in the controls (1.8%). After adjusting for age, sex, BMI, education, and individual ancestry the odds ratio was 1.60 but the 95% confidence interval was wide and overlapped 1 (0.52-4.86, P-value: 0.404). In order to characterize the distribution of the MGEA5-14 polymorphism in the relevant parental populations, we genotyped this variant in European (and European Americans), West African, and Native American samples. The T-allele was present at a frequency of 2.3% in Spain, 4.2% in European Americans, and 13% in Western Africans, but was absent in two Native American samples from Mexico and Peru. Given the low frequency of the T-allele, further studies using large sample sizes will be required to confirm the role of this variant in T2D.

Original languageEnglish (US)
Pages (from-to)593-596
Number of pages4
JournalAmerican Journal of Human Biology
Volume19
Issue number4
DOIs
StatePublished - Jul 2007
Externally publishedYes

Fingerprint

diabetes
Mexico
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
chronic illness
allele
polymorphism
North American Indians
genetic polymorphism
Gene Frequency
American Indians
alleles
Peru
Sex Education
sampling
ancestry
African Americans
Spain
Sample Size
Introns

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Anthropology

Cite this

Cameron, E. A., Martinez-Marignac, V. L., Chan, A., Valladares, A., Simmonds, L. V., Wacher, N., ... Parra, E. J. (2007). MGEA5-14 polymorphism and type 2 diabetes in Mexico City. American Journal of Human Biology, 19(4), 593-596. https://doi.org/10.1002/ajhb.20639

MGEA5-14 polymorphism and type 2 diabetes in Mexico City. / Cameron, E. A.; Martinez-Marignac, V. L.; Chan, A.; Valladares, A.; Simmonds, L. V.; Wacher, N.; Kumate, J.; McKeigue, P.; Shriver, M. D.; Kittles, Rick A; Cruz, M.; Parra, Esteban J.

In: American Journal of Human Biology, Vol. 19, No. 4, 07.2007, p. 593-596.

Research output: Contribution to journalArticle

Cameron, EA, Martinez-Marignac, VL, Chan, A, Valladares, A, Simmonds, LV, Wacher, N, Kumate, J, McKeigue, P, Shriver, MD, Kittles, RA, Cruz, M & Parra, EJ 2007, 'MGEA5-14 polymorphism and type 2 diabetes in Mexico City', American Journal of Human Biology, vol. 19, no. 4, pp. 593-596. https://doi.org/10.1002/ajhb.20639
Cameron EA, Martinez-Marignac VL, Chan A, Valladares A, Simmonds LV, Wacher N et al. MGEA5-14 polymorphism and type 2 diabetes in Mexico City. American Journal of Human Biology. 2007 Jul;19(4):593-596. https://doi.org/10.1002/ajhb.20639
Cameron, E. A. ; Martinez-Marignac, V. L. ; Chan, A. ; Valladares, A. ; Simmonds, L. V. ; Wacher, N. ; Kumate, J. ; McKeigue, P. ; Shriver, M. D. ; Kittles, Rick A ; Cruz, M. ; Parra, Esteban J. / MGEA5-14 polymorphism and type 2 diabetes in Mexico City. In: American Journal of Human Biology. 2007 ; Vol. 19, No. 4. pp. 593-596.
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