MgSO4 prevents left ventricular dysfunction in an animal model of preeclampsia

Brian J. Coates, Tom L. Broderick, Lyn M. Batia, Cynthia A. Standley

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Objective: We hypothesized that cardiac function would be reduced in a pregnant rat model of preeclampsia induced by L-NAME, a NOS inhibitor, and be reversed with magnesium sulfate prophylaxis. Study design: Female Sprague-Dawley rats were bred in-house. On gestational day 17, rats were anesthetized and osmotic minipumps were implanted to continuously deliver saline, L-NAME, or L-NAME and MgSO4. On gestational day 21, hearts were isolated and perfused in the working mode using Krebs Henseleit buffer. Results: Pregnant rats treated with L-NAME displayed significant hypertension compared to the saline-treated controls (P < 0.05). Moreover, cardiac output and cardiac work were significantly reduced in the L-NAME-treated rats compared to controls (P < 0.05). In the L-NAME-treated rats given MgSO4, cardiac function remained normal. Conclusion: Cardiac function is depressed in an animal model of preeclampsia induced by L-NAME infusion. MgSO4 prevented the reduction in cardiac function and is clearly beneficial in preserving normal heart function in preeclampsia.

Original languageEnglish (US)
Pages (from-to)1398-1403
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Volume195
Issue number5
DOIs
StatePublished - Nov 1 2006

Keywords

  • Heart
  • Hypertension
  • Magnesium
  • Preeclampsia
  • Rats

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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