MGST1, a new soldier of NRF2 in the battle against ferroptotic death

Matthew Dodson, Annadurai Anandhan, Donna D. Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

In this issue of Cell Chemical Biology, Kuang et al. (2021) identify microsomal glutathione-S-transferase 1 (MGST1) as an NRF2 target gene that suppresses ferroptosis in pancreatic cancer cells. Mechanistically, MGST1 binds ALOX5 during ferroptosis induction, inhibiting lipid peroxide production. Thus, MGST1 could represent a viable therapeutic target for treating pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)741-742
Number of pages2
JournalCell Chemical Biology
Volume28
Issue number6
DOIs
StatePublished - Jun 17 2021

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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