MIC2: a human pseudoautosomal gene.

P. N. Goodfellow, B. Pym, C. Pritchard, N. Ellis, M. Palmer, M. Smith, P. J. Goodfellow

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

MIC2 and XGR are the only known pseudoautosomal genes in man. MIC2 encodes the 12E7 antigen, a human cell-surface molecule of unknown function. XGR regulates, in cis, the expression of the XG and MIC2 genes. DNA probes derived from the MIC2 locus have been used in the construction of a meiotic map of the pseudoautosomal region and a long range restriction map into the X- and Y-specific chromosome domains. MIC2 is the most proximal marker in the pseudoautosomal region and recombination between the sex chromsomes only rarely includes the MIC2 locus. Our long-range restriction maps and chromosome walking experiments have localized the pseudoautosomal boundary within 40 kilobases adjacent to the 3' end of the MIC2 gene. The same maps have been used to predict the chromosomal location of TDF.

Original languageEnglish (US)
Pages (from-to)145-154
Number of pages10
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume322
Issue number1208
DOIs
StatePublished - Dec 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Goodfellow, P. N., Pym, B., Pritchard, C., Ellis, N., Palmer, M., Smith, M., & Goodfellow, P. J. (1988). MIC2: a human pseudoautosomal gene. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 322(1208), 145-154. https://doi.org/10.1098/rstb.1988.0122