Microangiectasias: Structural regulators of lymphocyte transmigration

Timothy W. Secomb, Moritz A. Konerding, Charles A. West, Mei Su, Alan J. Young, Steven J. Mentzer

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The migration of lymphocytes into inflammatory tissue requires the migrating cell to overcome mechanical forces produced by blood flow. A generally accepted hypothesis is that these forces are overcome by a multistep sequence of adhesive interactions between lymphocytes and endothelial cells. This hypothesis has been recently challenged by results demonstrating wall shear stress on the order of 20 dyn/cm2 in vivo and infrequent lymphocyteendothelial adhesion at wall shear stress >1-2 dyn/cm2 in vitro. Here, we show that lymphocyte slowing and transmigration in the skin is associated with microangiectasias, i.e., focal structural dilatations of microvessel segments. Microangiectasias are inducible within 4 days of the onset of inflammation and lead to a greater than 10-fold local reduction in wall shear stress. These findings support the hypothesis that a preparatory step to lymphocyte transmigration involves structural adaptations in the inflammatory microcirculation.

Original languageEnglish (US)
Pages (from-to)7231-7234
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number12
DOIs
StatePublished - Jun 10 2003

Keywords

  • Cell movement
  • Inflammation
  • Microcirculation
  • Microscopy
  • Ultrastructure

ASJC Scopus subject areas

  • General

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