Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult.

Charles Y. Chiu, Silvi Rouskin, Anita A Koshy, Anatoly Urisman, Kael Fischer, Shigeo Yagi, David Schnurr, Paul B. Eckburg, Lucy S. Tompkins, Brian G. Blackburn, Jason D. Merker, Bruce K. Patterson, Don Ganem, Joseph L. DeRisi

Research output: Contribution to journalArticle

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Abstract

A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness. The virus was identified in an endotracheal aspirate specimen, and the microarray results were confirmed by specific polymerase chain reaction and serological analysis for HPIV-4. Conventional clinical laboratory testing using an extensive panel of microbiological tests failed to yield a diagnosis. This case suggests that the potential severity of disease caused by HPIV-4 in adults may be greater than previously appreciated and illustrates the clinical utility of a microarray for broad-based viral pathogen screening.

Original languageEnglish (US)
JournalClinical Infectious Diseases
Volume43
Issue number8
DOIs
StatePublished - Oct 15 2006
Externally publishedYes

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Respiratory Insufficiency
Infection
San Francisco
Viral DNA
Oligonucleotide Array Sequence Analysis
Viruses
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult. / Chiu, Charles Y.; Rouskin, Silvi; Koshy, Anita A; Urisman, Anatoly; Fischer, Kael; Yagi, Shigeo; Schnurr, David; Eckburg, Paul B.; Tompkins, Lucy S.; Blackburn, Brian G.; Merker, Jason D.; Patterson, Bruce K.; Ganem, Don; DeRisi, Joseph L.

In: Clinical Infectious Diseases, Vol. 43, No. 8, 15.10.2006.

Research output: Contribution to journalArticle

Chiu, CY, Rouskin, S, Koshy, AA, Urisman, A, Fischer, K, Yagi, S, Schnurr, D, Eckburg, PB, Tompkins, LS, Blackburn, BG, Merker, JD, Patterson, BK, Ganem, D & DeRisi, JL 2006, 'Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult.', Clinical Infectious Diseases, vol. 43, no. 8. https://doi.org/10.1086/507896
Chiu, Charles Y. ; Rouskin, Silvi ; Koshy, Anita A ; Urisman, Anatoly ; Fischer, Kael ; Yagi, Shigeo ; Schnurr, David ; Eckburg, Paul B. ; Tompkins, Lucy S. ; Blackburn, Brian G. ; Merker, Jason D. ; Patterson, Bruce K. ; Ganem, Don ; DeRisi, Joseph L. / Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult. In: Clinical Infectious Diseases. 2006 ; Vol. 43, No. 8.
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