Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult.

Charles Y. Chiu, Silvi Rouskin, Anita Koshy, Anatoly Urisman, Kael Fischer, Shigeo Yagi, David Schnurr, Paul B. Eckburg, Lucy S. Tompkins, Brian G. Blackburn, Jason D. Merker, Bruce K. Patterson, Don Ganem, Joseph L. DeRisi

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness. The virus was identified in an endotracheal aspirate specimen, and the microarray results were confirmed by specific polymerase chain reaction and serological analysis for HPIV-4. Conventional clinical laboratory testing using an extensive panel of microbiological tests failed to yield a diagnosis. This case suggests that the potential severity of disease caused by HPIV-4 in adults may be greater than previously appreciated and illustrates the clinical utility of a microarray for broad-based viral pathogen screening.

Original languageEnglish (US)
Pages (from-to)e71-76
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume43
Issue number8
DOIs
StatePublished - Oct 15 2006

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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