Microbial biotransformation of 16a,17-epoxy-ent-kaurane-19-oic acid by beauveria sulfurescens ATCC 7159-F

Ricardo A. Furtado, G. M Kamal B Gunaherath, Jairo K. Bastos, Leslie Gunatilaka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Biotransformation of 16α,17-epoxy-ent-kaurane-19-oic acid (1) by Beauveria sulfurescens ATCC 7159-F led to the production of a new ent-kaurane diterpenoid, 7β,17-dihydroxy-ent-kaur-15-en-19-oic acid (7), and four other ent-kauranes (8 - 11), all of which were identified as their methyl esters. Compounds 9 and 10 were found to be new stereoisomers. Structures of these were established by the extensive usage of their spectroscopic characteristics.

Original languageEnglish (US)
Pages (from-to)1041-1044
Number of pages4
JournalNatural Product Communications
Volume8
Issue number8
StatePublished - Aug 2013

Fingerprint

Kaurane Diterpenes
Beauveria
Biotransformation
biotransformation
epoxides
stereoisomers
Acids
acids
diterpenoids
Stereoisomerism
Diterpenes
esters
Esters

Keywords

  • Beauveria sulfurescens
  • Biotransformation
  • Ent-kauranes
  • Structure elucidation

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Complementary and alternative medicine
  • Plant Science

Cite this

Microbial biotransformation of 16a,17-epoxy-ent-kaurane-19-oic acid by beauveria sulfurescens ATCC 7159-F. / Furtado, Ricardo A.; Gunaherath, G. M Kamal B; Bastos, Jairo K.; Gunatilaka, Leslie.

In: Natural Product Communications, Vol. 8, No. 8, 08.2013, p. 1041-1044.

Research output: Contribution to journalArticle

Furtado, Ricardo A. ; Gunaherath, G. M Kamal B ; Bastos, Jairo K. ; Gunatilaka, Leslie. / Microbial biotransformation of 16a,17-epoxy-ent-kaurane-19-oic acid by beauveria sulfurescens ATCC 7159-F. In: Natural Product Communications. 2013 ; Vol. 8, No. 8. pp. 1041-1044.
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