Microbial biotransformation of 16a,17-epoxy-ent-kaurane-19-oic acid by beauveria sulfurescens ATCC 7159-F

Ricardo A. Furtado, G. M.Kamal B. Gunaherath, Jairo K. Bastos, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticle

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Abstract

Biotransformation of 16α,17-epoxy-ent-kaurane-19-oic acid (1) by Beauveria sulfurescens ATCC 7159-F led to the production of a new ent-kaurane diterpenoid, 7β,17-dihydroxy-ent-kaur-15-en-19-oic acid (7), and four other ent-kauranes (8 - 11), all of which were identified as their methyl esters. Compounds 9 and 10 were found to be new stereoisomers. Structures of these were established by the extensive usage of their spectroscopic characteristics.

Original languageEnglish (US)
Pages (from-to)1041-1044
Number of pages4
JournalNatural Product Communications
Volume8
Issue number8
StatePublished - Aug 1 2013

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Keywords

  • Beauveria sulfurescens
  • Biotransformation
  • Ent-kauranes
  • Structure elucidation

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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