Microbial community dissimilarity for source tracking with application in forensic studies

Kyle M. Carte, Meng Lu, Qianwen Luo, Hongmei Jiang, Lingling An

Research output: Contribution to journalArticle

Abstract

Microbial source-tracking is a useful tool for trace evidence analysis in Forensics. Community- wide massively parallel sequencing profiles can bypass the need for satellite microbes or marker sets, which are unreliable when handling unstable samples. We propose a novel method utilizing Aitchison distance to select important suspects/sources, and then integrate it with existing algorithms in source tracking to estimate the proportions of microbial sample coming from important suspects/sources. A series of comprehensive simulation studies show that the proposed method is capable of accurate selection and therefore improves the performance of current methods such as Bayesian SourceTracker and FEAST in the presence of noise microbial sources.

Original languageEnglish (US)
Article numbere0236082
JournalPloS one
Volume15
Issue number7 July
DOIs
StatePublished - Jul 2020

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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