Microbial metabolism of 1-aminoanthracene by Beauveria bassiana

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12 Scopus citations

Abstract

The carcinogen and mutagen, 1-aminoanthracene, was efficiently metabolized by the fungal strain Beauveria bassiana ATCC 7159 to yield three new metabolites identified as 1-acetamido-5-[(4′-O-methyl-β-d-glucopyranosyl)oxy]anthracene, 1-acetamido-8-[(4′-O-methyl-β-d-glucopyranosyl)oxy]anthraquinone, and 1-acetamido-6-[(4′-O-methyl-β-d-glucopyranosyl)oxy]anthraquinone, together with 1-acetamidoanthracene and 1-acetamidoanthraquinone. Formation of these metabolites suggests that the metabolic pathways of 1-aminoanthracene in B. bassiana ATCC 7159 involve acetylation, oxidation, hydroxylation, and O-methylglucosylation.

Original languageEnglish (US)
Pages (from-to)5085-5089
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number9
DOIs
StatePublished - May 1 2008

Keywords

  • 1-Aminoanthracene
  • Acetylation
  • Beauveria bassiana
  • Biotransformaion
  • Hydroxylation
  • Microbial metabolism
  • O-Methylglucosylation
  • Oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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