Microbial transformation of curvularin

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The microbiological transformation of curvularin (1) with Beauveria bassiana ATCC 7159 afforded three new metabolites identified as curvularin-7-O-β-D-glucopyranoside (2), curvularin-4′-O-methyl-7-O- β-D-glucopyranoside (3), and 6-hydroxycurvularin-4′-O-methyl-6-O- β-D-glucopyranoside (4) resulting from hydroxylation, glucosidation, and methylglucosidation of the substrate. Isolation of 6-methyl-2,4-dihydroxyphenyl- 4′-O-methyl-1-O-β-D-glucopyranoside (5) from the fermentation broth of B. bassiana ATCC 7159 without any added substrate suggested that hydroxylase, glucosyl transferase, and methylase are constitutive enzymes of this organism.

Original languageEnglish (US)
Pages (from-to)1271-1273
Number of pages3
JournalJournal Of Natural Products
Volume68
Issue number8
DOIs
StatePublished - Aug 1 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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