Microbial transformation of curvularin

Jixun Zhan, Leslie Gunatilaka

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The microbiological transformation of curvularin (1) with Beauveria bassiana ATCC 7159 afforded three new metabolites identified as curvularin-7-O-β-D-glucopyranoside (2), curvularin-4′-O-methyl-7-O- β-D-glucopyranoside (3), and 6-hydroxycurvularin-4′-O-methyl-6-O- β-D-glucopyranoside (4) resulting from hydroxylation, glucosidation, and methylglucosidation of the substrate. Isolation of 6-methyl-2,4-dihydroxyphenyl- 4′-O-methyl-1-O-β-D-glucopyranoside (5) from the fermentation broth of B. bassiana ATCC 7159 without any added substrate suggested that hydroxylase, glucosyl transferase, and methylase are constitutive enzymes of this organism.

Original languageEnglish (US)
Pages (from-to)1271-1273
Number of pages3
JournalJournal of Natural Products
Volume68
Issue number8
DOIs
StatePublished - Aug 2005

Fingerprint

Beauveria
Beauveria bassiana
2,4-Dichlorophenoxyacetic Acid
Hydroxylation
Transferases
Mixed Function Oxygenases
Fermentation
hydroxylation
Substrates
Metabolites
transferases
Enzymes
fermentation
metabolites
organisms
enzymes
curvularin
6''-O-glucopyranoside

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Microbial transformation of curvularin. / Zhan, Jixun; Gunatilaka, Leslie.

In: Journal of Natural Products, Vol. 68, No. 8, 08.2005, p. 1271-1273.

Research output: Contribution to journalArticle

Zhan, Jixun ; Gunatilaka, Leslie. / Microbial transformation of curvularin. In: Journal of Natural Products. 2005 ; Vol. 68, No. 8. pp. 1271-1273.
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