Microbiome in Mechanisms of Asthma

Tara F. Carr, Rhonda Alkatib, Monica Kraft

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

The lung and gut microbiome are factors in asthma risk or protection. Relevant elements of the microbiome within both niches include the importance of the early life window for microbiome establishment, the diversity of bacteria, richness of bacteria, and effect of those bacteria on the local epithelium and immune system. Mechanisms of protection include direct anti-inflammatory action or induction of non–type 2 inflammation by certain bacterial colonies. The gut microbiome further impacts asthma risk through the contribution of metabolic products. This article reviews the mechanisms that connect the lung and gut microbiota to asthma development and severity.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalClinics in Chest Medicine
Volume40
Issue number1
DOIs
StatePublished - Mar 2019

Keywords

  • Asthma
  • Gut
  • Lung
  • Microbiome
  • Short-chain fatty acids
  • Type 2 inflammation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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