Microengineered platforms for cell mechanobiology

Deok Ho Kim, Pak Kin Wong, Jungyul Park, Andre Levchenko, Yu Sun

Research output: Contribution to journalArticle

255 Citations (Scopus)

Abstract

Mechanical forces play important roles in the regulation of various biological processes at the molecular and cellular level, such as gene expression, adhesion, migration, and cell fate, which are essential to the maintenance of tissue homeostasis. In this review, we discuss emerging bioengineered tools enabled by microscale technologies for studying the roles of mechanical forces in cell biology. In addition to traditional mechanobiology experimental techniques, we review recent advances of microelectromechanical systems (MEMS)-based approaches for cell mechanobiology and discuss how microengineered platforms can be used to generate in vivo-like micromechanical environment in in vitro settings for investigating cellular processes in normal and pathophysiological contexts. These capabilities also have significant implications for mechanical control of cell and tissue development and cell-based regenerative therapies.

Original languageEnglish (US)
Pages (from-to)203-233
Number of pages31
JournalAnnual Review of Biomedical Engineering
Volume11
DOIs
StatePublished - Aug 2009

Fingerprint

Biophysics
Tissue homeostasis
Cytology
Gene expression
MEMS
Biological Phenomena
Adhesion
Tissue
Cell Adhesion
Cell Movement
Cell Biology
Homeostasis
Maintenance
Technology
Gene Expression
Therapeutics

Keywords

  • Cell mechanics
  • Extracellular matrix
  • Mechanotransduction
  • Microelectromechanical systems (MEMS)
  • Microfabrication

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Microengineered platforms for cell mechanobiology. / Kim, Deok Ho; Wong, Pak Kin; Park, Jungyul; Levchenko, Andre; Sun, Yu.

In: Annual Review of Biomedical Engineering, Vol. 11, 08.2009, p. 203-233.

Research output: Contribution to journalArticle

Kim, Deok Ho ; Wong, Pak Kin ; Park, Jungyul ; Levchenko, Andre ; Sun, Yu. / Microengineered platforms for cell mechanobiology. In: Annual Review of Biomedical Engineering. 2009 ; Vol. 11. pp. 203-233.
@article{baa178d0c715402c8c1234ebd4c1341a,
title = "Microengineered platforms for cell mechanobiology",
abstract = "Mechanical forces play important roles in the regulation of various biological processes at the molecular and cellular level, such as gene expression, adhesion, migration, and cell fate, which are essential to the maintenance of tissue homeostasis. In this review, we discuss emerging bioengineered tools enabled by microscale technologies for studying the roles of mechanical forces in cell biology. In addition to traditional mechanobiology experimental techniques, we review recent advances of microelectromechanical systems (MEMS)-based approaches for cell mechanobiology and discuss how microengineered platforms can be used to generate in vivo-like micromechanical environment in in vitro settings for investigating cellular processes in normal and pathophysiological contexts. These capabilities also have significant implications for mechanical control of cell and tissue development and cell-based regenerative therapies.",
keywords = "Cell mechanics, Extracellular matrix, Mechanotransduction, Microelectromechanical systems (MEMS), Microfabrication",
author = "Kim, {Deok Ho} and Wong, {Pak Kin} and Jungyul Park and Andre Levchenko and Yu Sun",
year = "2009",
month = "8",
doi = "10.1146/annurev-bioeng-061008-124915",
language = "English (US)",
volume = "11",
pages = "203--233",
journal = "Annual Review of Biomedical Engineering",
issn = "1523-9829",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Microengineered platforms for cell mechanobiology

AU - Kim, Deok Ho

AU - Wong, Pak Kin

AU - Park, Jungyul

AU - Levchenko, Andre

AU - Sun, Yu

PY - 2009/8

Y1 - 2009/8

N2 - Mechanical forces play important roles in the regulation of various biological processes at the molecular and cellular level, such as gene expression, adhesion, migration, and cell fate, which are essential to the maintenance of tissue homeostasis. In this review, we discuss emerging bioengineered tools enabled by microscale technologies for studying the roles of mechanical forces in cell biology. In addition to traditional mechanobiology experimental techniques, we review recent advances of microelectromechanical systems (MEMS)-based approaches for cell mechanobiology and discuss how microengineered platforms can be used to generate in vivo-like micromechanical environment in in vitro settings for investigating cellular processes in normal and pathophysiological contexts. These capabilities also have significant implications for mechanical control of cell and tissue development and cell-based regenerative therapies.

AB - Mechanical forces play important roles in the regulation of various biological processes at the molecular and cellular level, such as gene expression, adhesion, migration, and cell fate, which are essential to the maintenance of tissue homeostasis. In this review, we discuss emerging bioengineered tools enabled by microscale technologies for studying the roles of mechanical forces in cell biology. In addition to traditional mechanobiology experimental techniques, we review recent advances of microelectromechanical systems (MEMS)-based approaches for cell mechanobiology and discuss how microengineered platforms can be used to generate in vivo-like micromechanical environment in in vitro settings for investigating cellular processes in normal and pathophysiological contexts. These capabilities also have significant implications for mechanical control of cell and tissue development and cell-based regenerative therapies.

KW - Cell mechanics

KW - Extracellular matrix

KW - Mechanotransduction

KW - Microelectromechanical systems (MEMS)

KW - Microfabrication

UR - http://www.scopus.com/inward/record.url?scp=67651149786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651149786&partnerID=8YFLogxK

U2 - 10.1146/annurev-bioeng-061008-124915

DO - 10.1146/annurev-bioeng-061008-124915

M3 - Article

C2 - 19400708

AN - SCOPUS:67651149786

VL - 11

SP - 203

EP - 233

JO - Annual Review of Biomedical Engineering

JF - Annual Review of Biomedical Engineering

SN - 1523-9829

ER -