Microfluidic devices for terahertz spectroscopy of live cells toward lab-on-a-chip applications

Qi Tang, Min Liang, Yi Lu, Pak Kin Wong, Gerald J. Wilmink, Donna Zhang, Hao Xin

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

THz spectroscopy is an emerging technique for studying the dynamics and interactions of cells and biomolecules, but many practical challenges still remain in experimental studies. We present a prototype of simple and inexpensive cell-trapping microfluidic chip for THz spectroscopic study of live cells. Cells are transported, trapped and concentrated into the THz exposure region by applying an AC bias signal while the chip maintains a steady temperature at 37 °C by resistive heating. We conduct some preliminary experiments on E. coli and T-cell solution and compare the transmission spectra of empty channels, channels filled with aqueous media only, and channels filled with aqueous media with un-concentrated and concentrated cells.

Original languageEnglish (US)
Article number476
JournalSensors (Switzerland)
Volume16
Issue number4
DOIs
StatePublished - Apr 4 2016

Keywords

  • Cell trapping
  • Lab-on-a-chip
  • Microfluidics
  • THz spectroscopy

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

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