Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides

Sonja Krane, So Ra Kim, Leif M Abrell, Koji Nakanishi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Microphysiometry was used to evaluate the effects of terpene trilactone and flavonoid constituents of Ginkgo biloba on human platelet-activating-factor receptor (PAFR). Inhibition of the platelet-activating factor response by terpene trilactones was confirmed using this functional assay. Ginkgolide B (GB) and 10-O-benzyl-GB showed the strongest inhibition (81 and 93%, resp.) of the PAFR response, while the flavonoids rutin, quercetin, and kaempferol showed negligible response inhibition. G. biloba extract mixtures were also tested, and results indicate possible synergistic effects among various components.

Original languageEnglish (US)
Pages (from-to)3776-3786
Number of pages11
JournalHelvetica Chimica Acta
Volume86
Issue number11
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

ginkgolide B
Ginkgolides
Ginkgo biloba
Terpenes
Platelets
platelets
Flavonoids
terpenes
Rutin
Platelet Activating Factor
Quercetin
Assays
platelet activating factor receptor
trilactone

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides. / Krane, Sonja; Kim, So Ra; Abrell, Leif M; Nakanishi, Koji.

In: Helvetica Chimica Acta, Vol. 86, No. 11, 2003, p. 3776-3786.

Research output: Contribution to journalArticle

Krane, Sonja ; Kim, So Ra ; Abrell, Leif M ; Nakanishi, Koji. / Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides. In: Helvetica Chimica Acta. 2003 ; Vol. 86, No. 11. pp. 3776-3786.
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