Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides

Sonja Krane, So Ra Kim, Leif M. Abrell, Koji Nakanishi

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Microphysiometry was used to evaluate the effects of terpene trilactone and flavonoid constituents of Ginkgo biloba on human platelet-activating-factor receptor (PAFR). Inhibition of the platelet-activating factor response by terpene trilactones was confirmed using this functional assay. Ginkgolide B (GB) and 10-O-benzyl-GB showed the strongest inhibition (81 and 93%, resp.) of the PAFR response, while the flavonoids rutin, quercetin, and kaempferol showed negligible response inhibition. G. biloba extract mixtures were also tested, and results indicate possible synergistic effects among various components.

Original languageEnglish (US)
Pages (from-to)3776-3786
Number of pages11
JournalHelvetica Chimica Acta
Volume86
Issue number11
DOIs
StatePublished - Dec 29 2003

ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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