MicroRNA Changes in Firefighters

Kyoung Sook Jeong, Jin Zhou, Stephanie C. Griffin, Elizabeth T. Jacobs, Devi Dearmon-Moore, Jing Zhai, Sally R. Littau, John Gulotta, Paul Moore, Wayne F. Peate, Crystal M. Richt, Jefferey L. Burgess

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objectives: Firefighters have elevated cancer incidence and mortality rates. MicroRNAs play prominent roles in carcinogenesis, but have not been previously evaluated in firefighters. Methods: Blood from 52 incumbent and 45 new recruit nonsmoking firefighters was analyzed for microRNA expression, and the results adjusted for age, obesity, ethnicity, and multiple comparisons. Results: Nine microRNAs were identified with at least a 1.5-fold significant difference between groups. All six microRNAs with decreased expression in incumbent firefighters have been reported to have tumor suppressor activity or are associated with cancer survival, and two of the three microRNAs with increased expression in incumbent firefighters have activities consistent with cancer promotion, with the remaining microRNA associated with neurological disease. Conclusion: Incumbent firefighters showed differential microRNA expression compared with new recruits, providing potential mechanisms for increased cancer risk in firefighters.

Original languageEnglish (US)
Pages (from-to)469-474
Number of pages6
JournalJournal of occupational and environmental medicine
Volume60
Issue number5
DOIs
StatePublished - May 1 2018

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Keywords

  • cancer
  • firefighter
  • microRNA

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Jeong, K. S., Zhou, J., Griffin, S. C., Jacobs, E. T., Dearmon-Moore, D., Zhai, J., Littau, S. R., Gulotta, J., Moore, P., Peate, W. F., Richt, C. M., & Burgess, J. L. (2018). MicroRNA Changes in Firefighters. Journal of occupational and environmental medicine, 60(5), 469-474. https://doi.org/10.1097/JOM.0000000000001307