MicroRNAs in Inflammatory Lung Disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inflammatory lung diseases include both acute inflammatory diseases such as acute respiratory distress syndrome (ARDS) and chronic inflammatory diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis and sarcoidosis. Both acute and chronic inflammatory lung diseases are associated with airway inflammation and are influenced by a combination of environmental, genetic, and epigenetic components. Epigenetic regulation, including microRNA (miRNA), of gene expression contributes to inflammatory lung disease development and severity. With the advancement of "omics" technology, miRNA expression and function in inflammatory lung diseases have been well studied, leading to a clear conclusion that miRNAs are differentially expressed under inflammatory lung disease conditions and contribute to genomic dysregulation in these diseases. Here we summarized the most up-to-date findings of miRNA in the inflammatory lung diseases including asthma, ARDS, COPD, cystic fibrosis, and sarcoidosis, and clinical implications of miRNA in these diseases. miRNAs are valued to be served as biomarkers, diagnostic tools, as well as therapeutic targets of inflammatory lung diseases.

Original languageEnglish (US)
Title of host publicationTranslating MicroRNAs to the Clinic
PublisherElsevier Inc.
Pages135-177
Number of pages43
ISBN (Print)9780128005538
DOIs
StatePublished - Jan 1 2017

Keywords

  • ARDS
  • Asthma
  • COPD
  • Cystic fibrosis
  • IPF
  • MiRNA
  • Sarcoidosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'MicroRNAs in Inflammatory Lung Disease'. Together they form a unique fingerprint.

Cite this