Microvascular dysfunction following primary percutaneous coronary intervention in the setting of ST-elevation myocardial infarction

Radhakrishnan Ramaraj, Mohammad R Movahed

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Primary percutaneous coronary intervention (PCI) is an established reperfusion strategy in the treatment of acute myocardial infarction with ST-segment elevation (STEMI). Nevertheless, myocardial damage is not terminated immediately, even with successful primary PCI, which eliminates the epicardial occlusion. Despite the success of contemporary reperfusion therapy and effective restoration of epicardial coronary flow, many patients have suboptimal flow at the tissue level within the myocardium. Studies indicate that these patients have a decreased recovery of left ventricular function and poor long-term prognosis. This could be due to reperfusion injury, embolization of epicardial thrombus or plaque debris jeopardizing tissue-level perfusion. This article attempts to review the process of microvascular dysfunction following reperfusion of STEMI with primary PCI and different strategies tried thus far to improve this.

Original languageEnglish (US)
Pages (from-to)603-614
Number of pages12
JournalJournal of Invasive Cardiology
Volume20
Issue number11
StatePublished - Nov 2008

Fingerprint

Percutaneous Coronary Intervention
Reperfusion
Reperfusion Injury
Left Ventricular Function
Myocardium
Thrombosis
Perfusion
Therapeutics
ST Elevation Myocardial Infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Microvascular dysfunction following primary percutaneous coronary intervention in the setting of ST-elevation myocardial infarction. / Ramaraj, Radhakrishnan; Movahed, Mohammad R.

In: Journal of Invasive Cardiology, Vol. 20, No. 11, 11.2008, p. 603-614.

Research output: Contribution to journalArticle

@article{504422db3b3b4bdda7008191c3a64aec,
title = "Microvascular dysfunction following primary percutaneous coronary intervention in the setting of ST-elevation myocardial infarction",
abstract = "Primary percutaneous coronary intervention (PCI) is an established reperfusion strategy in the treatment of acute myocardial infarction with ST-segment elevation (STEMI). Nevertheless, myocardial damage is not terminated immediately, even with successful primary PCI, which eliminates the epicardial occlusion. Despite the success of contemporary reperfusion therapy and effective restoration of epicardial coronary flow, many patients have suboptimal flow at the tissue level within the myocardium. Studies indicate that these patients have a decreased recovery of left ventricular function and poor long-term prognosis. This could be due to reperfusion injury, embolization of epicardial thrombus or plaque debris jeopardizing tissue-level perfusion. This article attempts to review the process of microvascular dysfunction following reperfusion of STEMI with primary PCI and different strategies tried thus far to improve this.",
author = "Radhakrishnan Ramaraj and Movahed, {Mohammad R}",
year = "2008",
month = "11",
language = "English (US)",
volume = "20",
pages = "603--614",
journal = "Journal of Invasive Cardiology",
issn = "1042-3931",
publisher = "HMP Communications",
number = "11",

}

TY - JOUR

T1 - Microvascular dysfunction following primary percutaneous coronary intervention in the setting of ST-elevation myocardial infarction

AU - Ramaraj, Radhakrishnan

AU - Movahed, Mohammad R

PY - 2008/11

Y1 - 2008/11

N2 - Primary percutaneous coronary intervention (PCI) is an established reperfusion strategy in the treatment of acute myocardial infarction with ST-segment elevation (STEMI). Nevertheless, myocardial damage is not terminated immediately, even with successful primary PCI, which eliminates the epicardial occlusion. Despite the success of contemporary reperfusion therapy and effective restoration of epicardial coronary flow, many patients have suboptimal flow at the tissue level within the myocardium. Studies indicate that these patients have a decreased recovery of left ventricular function and poor long-term prognosis. This could be due to reperfusion injury, embolization of epicardial thrombus or plaque debris jeopardizing tissue-level perfusion. This article attempts to review the process of microvascular dysfunction following reperfusion of STEMI with primary PCI and different strategies tried thus far to improve this.

AB - Primary percutaneous coronary intervention (PCI) is an established reperfusion strategy in the treatment of acute myocardial infarction with ST-segment elevation (STEMI). Nevertheless, myocardial damage is not terminated immediately, even with successful primary PCI, which eliminates the epicardial occlusion. Despite the success of contemporary reperfusion therapy and effective restoration of epicardial coronary flow, many patients have suboptimal flow at the tissue level within the myocardium. Studies indicate that these patients have a decreased recovery of left ventricular function and poor long-term prognosis. This could be due to reperfusion injury, embolization of epicardial thrombus or plaque debris jeopardizing tissue-level perfusion. This article attempts to review the process of microvascular dysfunction following reperfusion of STEMI with primary PCI and different strategies tried thus far to improve this.

UR - http://www.scopus.com/inward/record.url?scp=62449239613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62449239613&partnerID=8YFLogxK

M3 - Article

C2 - 18987402

AN - SCOPUS:62449239613

VL - 20

SP - 603

EP - 614

JO - Journal of Invasive Cardiology

JF - Journal of Invasive Cardiology

SN - 1042-3931

IS - 11

ER -