Midgut Mitochondrial Function as a Gatekeeper for Malaria Parasite Infection and Development in the Mosquito Host

Shirley Luckhart, Michael A. Riehle

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Across diverse organisms, various physiologies are profoundly regulated by mitochondrial function, which is defined by mitochondrial fusion, biogenesis, oxidative phosphorylation (OXPHOS), and mitophagy. Based on our data and significant published studies from Caenorhabditis elegans, Drosophila melanogaster and mammals, we propose that midgut mitochondria control midgut health and the health of other tissues in vector mosquitoes. Specifically, we argue that trade-offs among resistance to infection, metabolism, lifespan, and reproduction in vector mosquitoes are fundamentally controlled both locally and systemically by midgut mitochondrial function.

Original languageEnglish (US)
Article number593159
JournalFrontiers in Cellular and Infection Microbiology
Volume10
DOIs
StatePublished - Dec 11 2020

Keywords

  • Anopheles
  • Plasmodium
  • immunity
  • malaria
  • midgut
  • mitochondria
  • mosquito
  • resistance

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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