Midline (Central) fluid percussion model of traumatic brain injury

Rachel K. Rowe, Daniel R. Griffiths, Jonathan Lifshitz

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Abstract

Research models of traumatic brain injury (TBI) hold significant validity towards the human condition, with each model replicating a subset of clinical features and symptoms. After 30 years of characterization and implementation, fluid percussion injury (FPI) is firmly recognized as a clinically relevant model of TBI, encompassing concussion through severe injury. The midline variation of FPI may best represent mild and diffuse clinical brain injury, because of the acute behavioral deficits, the late onset of subtle behavioral morbidities, and the absence of gross histopathology. This chapter outlines the procedures for midline (diffuse) FPI in adult male rats and mice. With these procedures, it becomes possible to generate braininjured laboratory animals for studies of injury-induced pathophysiology and behavioral deficits, for which rational therapeutic interventions can be implemented.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages211-230
Number of pages20
Volume1462
DOIs
StatePublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1462
ISSN (Print)1064-3745

Keywords

  • Concussion
  • Diffuse
  • Experimental model
  • Fencing response
  • Fluid percussion
  • Mouse
  • Postoperative care
  • Rat
  • Righting reflex
  • Rodent
  • Trauma
  • Traumatic brain injury (TBI)

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology
  • Genetics

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