Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest

Michael Holzer, Fritz Sterz, J. M. Darby, S. A. Padosch, Karl B Kern, B. W. Böttiger, K. H. Polderman, A. R J Girbes, M. Holzer, S. A. Bernard, M. D. Buist, P. Safar, P. M. Kochanek

Research output: Contribution to journalArticle

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Abstract

Background: Cardiac arrest with widespread cerebral ischemia frequently leads to severe neurologic impairment. We studied whether mild systemic hypothermia increases the rate of neurologic recovery after resuscitation from cardiac arrest due to ventricular fibrillation. Methods: In this multicenter trial with blinded assessment of the outcome, patients who had been resuscitated after cardiac arrest due to ventricular fibrillation were randomly assigned to undergo therapeutic hypothermia (target temperature, 32°C to 34°C, measured in the bladder) over a period of 24 hours or to receive standard treatment with normothermia. The primary end point was a favorable neurologic outcome within six months after cardiac arrest; secondary end points were mortality within six months and the rate of complications within seven days. Results: Seventy-five of the 136 patients in the hypothermia group for whom data were available (55 percent) had a favorable neurologic outcome (cerebral-performance category, 1 [good recovery] or 2 [moderate disability]), as compared with 54 of 137 (39 percent) in the normothermia group (risk ratio, 1.40; 95 percent confidence interval, 1.08 to 1.81). Mortality at six months was 41 percent in the hypothermia group (56 of 137 patients died), as compared with 55 percent in the normothermia group (76 of 138 patients; risk ratio, 0.74; 95 percent confidence interval, 0.58 to 0.95). The complication rate did not differ significantly between the two groups. Conclusions: In patients who have been successfully resuscitated after cardiac arrest due to ventricular fibrillation, therapeutic mild hypothermia increased the rate of a favorable neurologic outcome and reduced mortality.

Original languageEnglish (US)
Pages (from-to)549-556
Number of pages8
JournalNew England Journal of Medicine
Volume346
Issue number8
DOIs
StatePublished - Feb 21 2002
Externally publishedYes

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Induced Hypothermia
Heart Arrest
Nervous System
Ventricular Fibrillation
Hypothermia
Mortality
Patient Outcome Assessment
Odds Ratio
Confidence Intervals
Brain Ischemia
Resuscitation
Multicenter Studies
Urinary Bladder
Temperature

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Holzer, M., Sterz, F., Darby, J. M., Padosch, S. A., Kern, K. B., Böttiger, B. W., ... Kochanek, P. M. (2002). Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. New England Journal of Medicine, 346(8), 549-556. https://doi.org/10.1056/NEJMoa012689

Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. / Holzer, Michael; Sterz, Fritz; Darby, J. M.; Padosch, S. A.; Kern, Karl B; Böttiger, B. W.; Polderman, K. H.; Girbes, A. R J; Holzer, M.; Bernard, S. A.; Buist, M. D.; Safar, P.; Kochanek, P. M.

In: New England Journal of Medicine, Vol. 346, No. 8, 21.02.2002, p. 549-556.

Research output: Contribution to journalArticle

Holzer, M, Sterz, F, Darby, JM, Padosch, SA, Kern, KB, Böttiger, BW, Polderman, KH, Girbes, ARJ, Holzer, M, Bernard, SA, Buist, MD, Safar, P & Kochanek, PM 2002, 'Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest', New England Journal of Medicine, vol. 346, no. 8, pp. 549-556. https://doi.org/10.1056/NEJMoa012689
Holzer, Michael ; Sterz, Fritz ; Darby, J. M. ; Padosch, S. A. ; Kern, Karl B ; Böttiger, B. W. ; Polderman, K. H. ; Girbes, A. R J ; Holzer, M. ; Bernard, S. A. ; Buist, M. D. ; Safar, P. ; Kochanek, P. M. / Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. In: New England Journal of Medicine. 2002 ; Vol. 346, No. 8. pp. 549-556.
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T1 - Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest

AU - Holzer, Michael

AU - Sterz, Fritz

AU - Darby, J. M.

AU - Padosch, S. A.

AU - Kern, Karl B

AU - Böttiger, B. W.

AU - Polderman, K. H.

AU - Girbes, A. R J

AU - Holzer, M.

AU - Bernard, S. A.

AU - Buist, M. D.

AU - Safar, P.

AU - Kochanek, P. M.

PY - 2002/2/21

Y1 - 2002/2/21

N2 - Background: Cardiac arrest with widespread cerebral ischemia frequently leads to severe neurologic impairment. We studied whether mild systemic hypothermia increases the rate of neurologic recovery after resuscitation from cardiac arrest due to ventricular fibrillation. Methods: In this multicenter trial with blinded assessment of the outcome, patients who had been resuscitated after cardiac arrest due to ventricular fibrillation were randomly assigned to undergo therapeutic hypothermia (target temperature, 32°C to 34°C, measured in the bladder) over a period of 24 hours or to receive standard treatment with normothermia. The primary end point was a favorable neurologic outcome within six months after cardiac arrest; secondary end points were mortality within six months and the rate of complications within seven days. Results: Seventy-five of the 136 patients in the hypothermia group for whom data were available (55 percent) had a favorable neurologic outcome (cerebral-performance category, 1 [good recovery] or 2 [moderate disability]), as compared with 54 of 137 (39 percent) in the normothermia group (risk ratio, 1.40; 95 percent confidence interval, 1.08 to 1.81). Mortality at six months was 41 percent in the hypothermia group (56 of 137 patients died), as compared with 55 percent in the normothermia group (76 of 138 patients; risk ratio, 0.74; 95 percent confidence interval, 0.58 to 0.95). The complication rate did not differ significantly between the two groups. Conclusions: In patients who have been successfully resuscitated after cardiac arrest due to ventricular fibrillation, therapeutic mild hypothermia increased the rate of a favorable neurologic outcome and reduced mortality.

AB - Background: Cardiac arrest with widespread cerebral ischemia frequently leads to severe neurologic impairment. We studied whether mild systemic hypothermia increases the rate of neurologic recovery after resuscitation from cardiac arrest due to ventricular fibrillation. Methods: In this multicenter trial with blinded assessment of the outcome, patients who had been resuscitated after cardiac arrest due to ventricular fibrillation were randomly assigned to undergo therapeutic hypothermia (target temperature, 32°C to 34°C, measured in the bladder) over a period of 24 hours or to receive standard treatment with normothermia. The primary end point was a favorable neurologic outcome within six months after cardiac arrest; secondary end points were mortality within six months and the rate of complications within seven days. Results: Seventy-five of the 136 patients in the hypothermia group for whom data were available (55 percent) had a favorable neurologic outcome (cerebral-performance category, 1 [good recovery] or 2 [moderate disability]), as compared with 54 of 137 (39 percent) in the normothermia group (risk ratio, 1.40; 95 percent confidence interval, 1.08 to 1.81). Mortality at six months was 41 percent in the hypothermia group (56 of 137 patients died), as compared with 55 percent in the normothermia group (76 of 138 patients; risk ratio, 0.74; 95 percent confidence interval, 0.58 to 0.95). The complication rate did not differ significantly between the two groups. Conclusions: In patients who have been successfully resuscitated after cardiac arrest due to ventricular fibrillation, therapeutic mild hypothermia increased the rate of a favorable neurologic outcome and reduced mortality.

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