Mineralocorticoid receptor overexpression differentially modulates specific phases of spatial and nonspatial memory

Deveroux Ferguson, Robert Sapolsky

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Glucocorticoids (GCs) and stress modulate specific phases of information processing. The modulatory affects of GCs on hippocampal function are thought to be mediated by the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). The GR plays a critical role in mediating the impairing effects of GCs on hippocampal function. Conversely, activation of MR facilitates hippocampal function. The high affinity of MR for GCs suggests that the receptor protein levels play a key role in regulating the beneficial effects of MR-mediated gene transcription. Using herpes simplex vectors, we transiently increased MR levels in dentate gyrus granule cells, which in turn enhanced MR signaling. We then examined its effects on spatial and nonspatial memory consolidation and retrieval using the object placement and object recognition task. Additionally, we assessed whether an increased MR signal could block the impairing effects of high GCs on memory retrieval. Rats overexpressing MR displayed an enhancement in the consolidation of nonspatial memory relative to rats expressing green fluorescent protein and suggest the potential for gene transfer techniques for enhancing cognition during stress. Moreover, rats overexpressing MR were spared from the disruptive effects of high GCs on the retrieval of nonspatial memory. Thus, this study illustrates the critical role of MR in mediating the retrieval and consolidation of nonspatial memory.

Original languageEnglish (US)
Pages (from-to)8046-8052
Number of pages7
JournalJournal of Neuroscience
Volume27
Issue number30
DOIs
StatePublished - Jul 25 2007
Externally publishedYes

Fingerprint

Mineralocorticoid Receptors
Glucocorticoids
Glucocorticoid Receptors
Spatial Memory
Gene Transfer Techniques
Herpes Simplex
Dentate Gyrus
Green Fluorescent Proteins
Automatic Data Processing
Cognition

Keywords

  • Corticosterone
  • Learning and memory
  • Mineralocorticoid receptor
  • Nonspatial memory
  • Spatial memory
  • Viral vector

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mineralocorticoid receptor overexpression differentially modulates specific phases of spatial and nonspatial memory. / Ferguson, Deveroux; Sapolsky, Robert.

In: Journal of Neuroscience, Vol. 27, No. 30, 25.07.2007, p. 8046-8052.

Research output: Contribution to journalArticle

@article{0e9e77dd15994d7f833567e40e446eca,
title = "Mineralocorticoid receptor overexpression differentially modulates specific phases of spatial and nonspatial memory",
abstract = "Glucocorticoids (GCs) and stress modulate specific phases of information processing. The modulatory affects of GCs on hippocampal function are thought to be mediated by the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). The GR plays a critical role in mediating the impairing effects of GCs on hippocampal function. Conversely, activation of MR facilitates hippocampal function. The high affinity of MR for GCs suggests that the receptor protein levels play a key role in regulating the beneficial effects of MR-mediated gene transcription. Using herpes simplex vectors, we transiently increased MR levels in dentate gyrus granule cells, which in turn enhanced MR signaling. We then examined its effects on spatial and nonspatial memory consolidation and retrieval using the object placement and object recognition task. Additionally, we assessed whether an increased MR signal could block the impairing effects of high GCs on memory retrieval. Rats overexpressing MR displayed an enhancement in the consolidation of nonspatial memory relative to rats expressing green fluorescent protein and suggest the potential for gene transfer techniques for enhancing cognition during stress. Moreover, rats overexpressing MR were spared from the disruptive effects of high GCs on the retrieval of nonspatial memory. Thus, this study illustrates the critical role of MR in mediating the retrieval and consolidation of nonspatial memory.",
keywords = "Corticosterone, Learning and memory, Mineralocorticoid receptor, Nonspatial memory, Spatial memory, Viral vector",
author = "Deveroux Ferguson and Robert Sapolsky",
year = "2007",
month = "7",
day = "25",
doi = "10.1523/JNEUROSCI.1187-07.2007",
language = "English (US)",
volume = "27",
pages = "8046--8052",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "30",

}

TY - JOUR

T1 - Mineralocorticoid receptor overexpression differentially modulates specific phases of spatial and nonspatial memory

AU - Ferguson, Deveroux

AU - Sapolsky, Robert

PY - 2007/7/25

Y1 - 2007/7/25

N2 - Glucocorticoids (GCs) and stress modulate specific phases of information processing. The modulatory affects of GCs on hippocampal function are thought to be mediated by the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). The GR plays a critical role in mediating the impairing effects of GCs on hippocampal function. Conversely, activation of MR facilitates hippocampal function. The high affinity of MR for GCs suggests that the receptor protein levels play a key role in regulating the beneficial effects of MR-mediated gene transcription. Using herpes simplex vectors, we transiently increased MR levels in dentate gyrus granule cells, which in turn enhanced MR signaling. We then examined its effects on spatial and nonspatial memory consolidation and retrieval using the object placement and object recognition task. Additionally, we assessed whether an increased MR signal could block the impairing effects of high GCs on memory retrieval. Rats overexpressing MR displayed an enhancement in the consolidation of nonspatial memory relative to rats expressing green fluorescent protein and suggest the potential for gene transfer techniques for enhancing cognition during stress. Moreover, rats overexpressing MR were spared from the disruptive effects of high GCs on the retrieval of nonspatial memory. Thus, this study illustrates the critical role of MR in mediating the retrieval and consolidation of nonspatial memory.

AB - Glucocorticoids (GCs) and stress modulate specific phases of information processing. The modulatory affects of GCs on hippocampal function are thought to be mediated by the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). The GR plays a critical role in mediating the impairing effects of GCs on hippocampal function. Conversely, activation of MR facilitates hippocampal function. The high affinity of MR for GCs suggests that the receptor protein levels play a key role in regulating the beneficial effects of MR-mediated gene transcription. Using herpes simplex vectors, we transiently increased MR levels in dentate gyrus granule cells, which in turn enhanced MR signaling. We then examined its effects on spatial and nonspatial memory consolidation and retrieval using the object placement and object recognition task. Additionally, we assessed whether an increased MR signal could block the impairing effects of high GCs on memory retrieval. Rats overexpressing MR displayed an enhancement in the consolidation of nonspatial memory relative to rats expressing green fluorescent protein and suggest the potential for gene transfer techniques for enhancing cognition during stress. Moreover, rats overexpressing MR were spared from the disruptive effects of high GCs on the retrieval of nonspatial memory. Thus, this study illustrates the critical role of MR in mediating the retrieval and consolidation of nonspatial memory.

KW - Corticosterone

KW - Learning and memory

KW - Mineralocorticoid receptor

KW - Nonspatial memory

KW - Spatial memory

KW - Viral vector

UR - http://www.scopus.com/inward/record.url?scp=34547395264&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547395264&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.1187-07.2007

DO - 10.1523/JNEUROSCI.1187-07.2007

M3 - Article

C2 - 17652595

AN - SCOPUS:34547395264

VL - 27

SP - 8046

EP - 8052

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 30

ER -