Miniature endoscope for a combined OCT-LIF system

Alex Tumlinson, Lida Hariri, Jennifer K Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

An endoscopic system that provides simultaneous cross-sectional imaging and fluorescence spectroscopy is described. The first application of this device was the investigation of mouse colon cancer in vivo. This system combined optical coherence tomography (OCT), which provided high-resolution cross-sectional structural information in the form of a two-dimensional image, and laser induced fluorescence (LIF), which yielded histochemical information about the tissue. The design challenge and solution of packaging these two systems with widely different optical requirements are described in detail. The illumination geometry of the endoscope was similar to earlier published OCT and LIF catheter endoscope designs. However, several unique design challenges encountered in combining these two systems have been addressed. The use of a rodprism to reduce the asymmetry in the OCT beam caused by a cylindrical window is presented. Materials selection for use with wavelengths from 325nm - 1310nm presented a challenge usually avoided in OCT endoscopes. Preliminary mouse colon data collected with this endoscopic device is compared with previous experiments performed by researchers in our lab working with an earlier bulk-optic, combined OCT-LIF system.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsV.V. Tuchin, J.A. Izatt, J.G. Fujimoto
Pages129-138
Number of pages10
Volume4956
DOIs
Publication statusPublished - 2003
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII - San Jose, CA, United States
Duration: Jan 27 2003Jan 29 2003

Other

OtherPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII
CountryUnited States
CitySan Jose, CA
Period1/27/031/29/03

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Keywords

  • Catheter
  • Colon
  • Laser induced fluorescence
  • Mouse
  • Multi-modal
  • Optical coherence tomography

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Tumlinson, A., Hariri, L., & Barton, J. K. (2003). Miniature endoscope for a combined OCT-LIF system. In V. V. Tuchin, J. A. Izatt, & J. G. Fujimoto (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4956, pp. 129-138) https://doi.org/10.1117/12.477817