Miniature endoscope for a combined OCT-LIF system

Alex Tumlinson, Lida Hariri, Jennifer K Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

An endoscopic system that provides simultaneous cross-sectional imaging and fluorescence spectroscopy is described. The first application of this device was the investigation of mouse colon cancer in vivo. This system combined optical coherence tomography (OCT), which provided high-resolution cross-sectional structural information in the form of a two-dimensional image, and laser induced fluorescence (LIF), which yielded histochemical information about the tissue. The design challenge and solution of packaging these two systems with widely different optical requirements are described in detail. The illumination geometry of the endoscope was similar to earlier published OCT and LIF catheter endoscope designs. However, several unique design challenges encountered in combining these two systems have been addressed. The use of a rodprism to reduce the asymmetry in the OCT beam caused by a cylindrical window is presented. Materials selection for use with wavelengths from 325nm - 1310nm presented a challenge usually avoided in OCT endoscopes. Preliminary mouse colon data collected with this endoscopic device is compared with previous experiments performed by researchers in our lab working with an earlier bulk-optic, combined OCT-LIF system.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsV.V. Tuchin, J.A. Izatt, J.G. Fujimoto
Pages129-138
Number of pages10
Volume4956
DOIs
StatePublished - 2003
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII - San Jose, CA, United States
Duration: Jan 27 2003Jan 29 2003

Other

OtherPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII
CountryUnited States
CitySan Jose, CA
Period1/27/031/29/03

Fingerprint

endoscopes
Endoscopy
Optical tomography
laser induced fluorescence
tomography
Fluorescence
Lasers
mice
materials selection
Catheters
Fluorescence spectroscopy
packaging
Optics
Packaging
Lighting
cancer
illumination
asymmetry
optics
Tissue

Keywords

  • Catheter
  • Colon
  • Laser induced fluorescence
  • Mouse
  • Multi-modal
  • Optical coherence tomography

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Tumlinson, A., Hariri, L., & Barton, J. K. (2003). Miniature endoscope for a combined OCT-LIF system. In V. V. Tuchin, J. A. Izatt, & J. G. Fujimoto (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4956, pp. 129-138) https://doi.org/10.1117/12.477817

Miniature endoscope for a combined OCT-LIF system. / Tumlinson, Alex; Hariri, Lida; Barton, Jennifer K.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / V.V. Tuchin; J.A. Izatt; J.G. Fujimoto. Vol. 4956 2003. p. 129-138.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tumlinson, A, Hariri, L & Barton, JK 2003, Miniature endoscope for a combined OCT-LIF system. in VV Tuchin, JA Izatt & JG Fujimoto (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4956, pp. 129-138, PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII, San Jose, CA, United States, 1/27/03. https://doi.org/10.1117/12.477817
Tumlinson A, Hariri L, Barton JK. Miniature endoscope for a combined OCT-LIF system. In Tuchin VV, Izatt JA, Fujimoto JG, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4956. 2003. p. 129-138 https://doi.org/10.1117/12.477817
Tumlinson, Alex ; Hariri, Lida ; Barton, Jennifer K. / Miniature endoscope for a combined OCT-LIF system. Proceedings of SPIE - The International Society for Optical Engineering. editor / V.V. Tuchin ; J.A. Izatt ; J.G. Fujimoto. Vol. 4956 2003. pp. 129-138
@inproceedings{da98b5ee2b3b44b4bc2b6a37f6fec294,
title = "Miniature endoscope for a combined OCT-LIF system",
abstract = "An endoscopic system that provides simultaneous cross-sectional imaging and fluorescence spectroscopy is described. The first application of this device was the investigation of mouse colon cancer in vivo. This system combined optical coherence tomography (OCT), which provided high-resolution cross-sectional structural information in the form of a two-dimensional image, and laser induced fluorescence (LIF), which yielded histochemical information about the tissue. The design challenge and solution of packaging these two systems with widely different optical requirements are described in detail. The illumination geometry of the endoscope was similar to earlier published OCT and LIF catheter endoscope designs. However, several unique design challenges encountered in combining these two systems have been addressed. The use of a rodprism to reduce the asymmetry in the OCT beam caused by a cylindrical window is presented. Materials selection for use with wavelengths from 325nm - 1310nm presented a challenge usually avoided in OCT endoscopes. Preliminary mouse colon data collected with this endoscopic device is compared with previous experiments performed by researchers in our lab working with an earlier bulk-optic, combined OCT-LIF system.",
keywords = "Catheter, Colon, Laser induced fluorescence, Mouse, Multi-modal, Optical coherence tomography",
author = "Alex Tumlinson and Lida Hariri and Barton, {Jennifer K}",
year = "2003",
doi = "10.1117/12.477817",
language = "English (US)",
volume = "4956",
pages = "129--138",
editor = "V.V. Tuchin and J.A. Izatt and J.G. Fujimoto",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - Miniature endoscope for a combined OCT-LIF system

AU - Tumlinson, Alex

AU - Hariri, Lida

AU - Barton, Jennifer K

PY - 2003

Y1 - 2003

N2 - An endoscopic system that provides simultaneous cross-sectional imaging and fluorescence spectroscopy is described. The first application of this device was the investigation of mouse colon cancer in vivo. This system combined optical coherence tomography (OCT), which provided high-resolution cross-sectional structural information in the form of a two-dimensional image, and laser induced fluorescence (LIF), which yielded histochemical information about the tissue. The design challenge and solution of packaging these two systems with widely different optical requirements are described in detail. The illumination geometry of the endoscope was similar to earlier published OCT and LIF catheter endoscope designs. However, several unique design challenges encountered in combining these two systems have been addressed. The use of a rodprism to reduce the asymmetry in the OCT beam caused by a cylindrical window is presented. Materials selection for use with wavelengths from 325nm - 1310nm presented a challenge usually avoided in OCT endoscopes. Preliminary mouse colon data collected with this endoscopic device is compared with previous experiments performed by researchers in our lab working with an earlier bulk-optic, combined OCT-LIF system.

AB - An endoscopic system that provides simultaneous cross-sectional imaging and fluorescence spectroscopy is described. The first application of this device was the investigation of mouse colon cancer in vivo. This system combined optical coherence tomography (OCT), which provided high-resolution cross-sectional structural information in the form of a two-dimensional image, and laser induced fluorescence (LIF), which yielded histochemical information about the tissue. The design challenge and solution of packaging these two systems with widely different optical requirements are described in detail. The illumination geometry of the endoscope was similar to earlier published OCT and LIF catheter endoscope designs. However, several unique design challenges encountered in combining these two systems have been addressed. The use of a rodprism to reduce the asymmetry in the OCT beam caused by a cylindrical window is presented. Materials selection for use with wavelengths from 325nm - 1310nm presented a challenge usually avoided in OCT endoscopes. Preliminary mouse colon data collected with this endoscopic device is compared with previous experiments performed by researchers in our lab working with an earlier bulk-optic, combined OCT-LIF system.

KW - Catheter

KW - Colon

KW - Laser induced fluorescence

KW - Mouse

KW - Multi-modal

KW - Optical coherence tomography

UR - http://www.scopus.com/inward/record.url?scp=0345293355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345293355&partnerID=8YFLogxK

U2 - 10.1117/12.477817

DO - 10.1117/12.477817

M3 - Conference contribution

VL - 4956

SP - 129

EP - 138

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Tuchin, V.V.

A2 - Izatt, J.A.

A2 - Fujimoto, J.G.

ER -