Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement

Alexandre R. Tumlinson, Lida P. Hariri, Urs Utzinger, Jennifer K. Barton

Research output: Contribution to journalArticle

117 Scopus citations

Abstract

We have designed a multimodality system that combines optical coherence tomography (OCT) and laser-induced fluorescence (LIF) in a 2.0-mm-diameter endoscopic package. OCT provides ∼18-μm resolution cross-sectional structural information over a 6-mm field. LIF spectra are collected sequentially at submillimeter resolution across the same field and provide histochemical information about the tissue. We present the use of a rod prism to reduce the asymmetry in the OCT beam caused by a cylindrical window. The endoscope has been applied to investigate mouse colon cancer in vivo.

Original languageEnglish (US)
Pages (from-to)113-121
Number of pages9
JournalApplied optics
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

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