Minimizing the influence of fundus pigmentation on retinal vessel oximetry measurements

M. H. Smith, Kurt R Denninghoff, A. Lompado, J. B. Woodruff, L. W. Hillman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)

Abstract

The goal of making calibrated oxygen saturation measurements of blood in retinal arteries and veins via a noninvasive spectroscopic technique has nearly been realized. Semi-continuous advancement in the field of retinal vessel oximetry over the last three decades has resulted in several technologies that seem poised for commercialization. In this paper, we present our instrumentation and technique for making well-calibrated saturation measurements of the blood in retinal vessels. The Eye Oximeter (EOX) is a confocal scanning laser ophthalmoscope capable of acquiring multi-spectral images. Analysis of these spectral vessel images allows spectroscopic determination of the oxygen saturation of blood within each vessel. The primary emphasis of this paper is to illustrate the effect of fundus pigmentation on these oximetric measurements. We show that decreasing fundus reflectivity is mathematically similar to decreasing the vessel thickness. The apparent decreased vessel thickness is a direct consequence of scattering by red blood cells. We present in vitro and in vivo measurements that demonstrate an instrument calibration that is nearly independent of vessel diameter and fundus reflectivity.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsF. Manns, P.G. Soderberg, A. Ho
Pages135-145
Number of pages11
Volume4245
DOIs
StatePublished - 2001
Externally publishedYes
EventOphthalmic Technologies XI - San Jose, CA, United States
Duration: Jan 20 2001Jan 21 2001

Other

OtherOphthalmic Technologies XI
CountryUnited States
CitySan Jose, CA
Period1/20/011/21/01

Fingerprint

oximetry
vessels
Blood
blood
Oximeters
Oxygen
saturation
reflectance
Cells
Calibration
Scattering
commercialization
Scanning
erythrocytes
oxygen
arteries
Lasers
veins
scanning

Keywords

  • Noninvasive diagnosis
  • Oxygen saturation
  • Retina

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Smith, M. H., Denninghoff, K. R., Lompado, A., Woodruff, J. B., & Hillman, L. W. (2001). Minimizing the influence of fundus pigmentation on retinal vessel oximetry measurements. In F. Manns, P. G. Soderberg, & A. Ho (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4245, pp. 135-145) https://doi.org/10.1117/12.429265

Minimizing the influence of fundus pigmentation on retinal vessel oximetry measurements. / Smith, M. H.; Denninghoff, Kurt R; Lompado, A.; Woodruff, J. B.; Hillman, L. W.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / F. Manns; P.G. Soderberg; A. Ho. Vol. 4245 2001. p. 135-145.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Smith, MH, Denninghoff, KR, Lompado, A, Woodruff, JB & Hillman, LW 2001, Minimizing the influence of fundus pigmentation on retinal vessel oximetry measurements. in F Manns, PG Soderberg & A Ho (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4245, pp. 135-145, Ophthalmic Technologies XI, San Jose, CA, United States, 1/20/01. https://doi.org/10.1117/12.429265
Smith MH, Denninghoff KR, Lompado A, Woodruff JB, Hillman LW. Minimizing the influence of fundus pigmentation on retinal vessel oximetry measurements. In Manns F, Soderberg PG, Ho A, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4245. 2001. p. 135-145 https://doi.org/10.1117/12.429265
Smith, M. H. ; Denninghoff, Kurt R ; Lompado, A. ; Woodruff, J. B. ; Hillman, L. W. / Minimizing the influence of fundus pigmentation on retinal vessel oximetry measurements. Proceedings of SPIE - The International Society for Optical Engineering. editor / F. Manns ; P.G. Soderberg ; A. Ho. Vol. 4245 2001. pp. 135-145
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