Minireview Murine models for Acquired Immune Deficiency Syndrome

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The mouse has been suggested as a host for comparative studies of several aspects of Human Acquired Immune Deficiency Syndrome (AIDS). Models include studies where part or all of the genome of Human Immunodeficiency Virus (HIV) has been incorporated into murine DNA in living mice. However, the most promising oppurtunities for study of immunological changes, vaccine development, cofactor involvement in disease, and anti-retroviral and immunostimulatory drug testing involve infection with murine retroviruses which cause many functional changes similar to AIDS. The viruses' effects on immune systems are reviewed with special emphasis on LP-BM5 murine leukemia virus which infects T and B cells, and macrophages. LP-BM5 infection suppresses cell functions while causing polyclonal lymphocyte activation. Murine immunological characterization, availability of inbred mouse strains, economy of using mice versus primates or humans models, and similarity of immune change caused by murine retroviruses compared to those seen in AIDS caused by HIV encourage rapid development of the LP-BM5 murine leukemia model.

Original languageEnglish (US)
JournalLife Sciences
Volume44
Issue number3
DOIs
StatePublished - 1989

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Murine Acquired Immunodeficiency Syndrome
Viruses
Acquired Immunodeficiency Syndrome
Retroviridae
HIV
Murine Leukemia Viruses
Inbred Strains Mice
Lymphocyte Activation
Infection
Primates
Lymphocytes
Macrophages
Immune system
Immune System
Leukemia
B-Lymphocytes
Vaccines
Genome
T-Lymphocytes
Genes

ASJC Scopus subject areas

  • Pharmacology

Cite this

Minireview Murine models for Acquired Immune Deficiency Syndrome. / Watson, Ronald R.

In: Life Sciences, Vol. 44, No. 3, 1989.

Research output: Contribution to journalArticle

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