Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis

I. Rego-Pérez, F. J. Blanco, F. W. Roemer, A. Guermazi, D. Ran, E. L. Ashbeck, M. Fernández-Moreno, N. Oreiro, M. J. Hannon, D. J. Hunter, Chian K Kwoh

Research output: Contribution to journalArticle

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Abstract

Objective: Magnetic resonance imaging (MRI)-detected structural features are associated with increased risk of radiographic osteoarthritis (ROA). Specific mitochondrial DNA (mtDNA) haplogroups have been associated with incident ROA. Our objective was to compare the presence of MRI-detected structural features across mtDNA haplogroups among knees that developed incident ROA. Design: Knees from the Osteoarthritis Initiative (OAI) that developed incident ROA during 48 months follow-up were identified from Caucasian participants. mtDNA haplogroups were assigned based on a single base extension assay. MRIs were obtained annually between baseline and 4-year follow-up and scored using the MRI Osteoarthritis Knee Score (MOAKS). The association between mtDNA haplogroups and MRI-detected structural features was estimated using log-binomial regression. Participants who carried haplogroup H served as the reference group. Results: The sample included 255 participants contributing 277 knees that developed ROA. Haplogroups included H (116, 45%), J (17, 7%), T (26, 10%), Uk (61, 24%), and the remaining less common haplogroups (“others”) (35, 14%). Knees of participants with haplogroup J had significantly lower risk of medium/large bone marrow lesions (BMLs) in the medial compartment [3.2%, relative risks (RR) = 0.17; 95%CI: 0.05, 0.64; P = 0.009] compared to knees of participants who carried haplogroup H [16.3%], as did knees from participants within the “others” group [2.8%, RR = 0.20; 95%CI: 0.08, 0.55; P = 0.002], over the 4 year follow-up period. Conclusions: mtDNA haplogroup J was associated with lower risk of BMLs in the medial compartment among knees that developed ROA. Our results offer a potential hypothesis to explain the mechanism underlying the previously reported protective association between haplogroup J and ROA.

Original languageEnglish (US)
Pages (from-to)1562-1569
Number of pages8
JournalOsteoarthritis and Cartilage
Volume26
Issue number11
DOIs
StatePublished - Nov 1 2018

Fingerprint

Knee Osteoarthritis
Mitochondrial DNA
Osteoarthritis
Magnetic resonance imaging
DNA
Magnetic Resonance Imaging
Knee
Bone
Association reactions
Bone Marrow
Assays

Keywords

  • Bone marrow lesions
  • Haplogroups
  • Knee osteoarthritis
  • Meniscus
  • Mitochondrial DNA
  • MRI

ASJC Scopus subject areas

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine

Cite this

Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis. / Rego-Pérez, I.; Blanco, F. J.; Roemer, F. W.; Guermazi, A.; Ran, D.; Ashbeck, E. L.; Fernández-Moreno, M.; Oreiro, N.; Hannon, M. J.; Hunter, D. J.; Kwoh, Chian K.

In: Osteoarthritis and Cartilage, Vol. 26, No. 11, 01.11.2018, p. 1562-1569.

Research output: Contribution to journalArticle

Rego-Pérez, I, Blanco, FJ, Roemer, FW, Guermazi, A, Ran, D, Ashbeck, EL, Fernández-Moreno, M, Oreiro, N, Hannon, MJ, Hunter, DJ & Kwoh, CK 2018, 'Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis', Osteoarthritis and Cartilage, vol. 26, no. 11, pp. 1562-1569. https://doi.org/10.1016/j.joca.2018.06.016
Rego-Pérez, I. ; Blanco, F. J. ; Roemer, F. W. ; Guermazi, A. ; Ran, D. ; Ashbeck, E. L. ; Fernández-Moreno, M. ; Oreiro, N. ; Hannon, M. J. ; Hunter, D. J. ; Kwoh, Chian K. / Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis. In: Osteoarthritis and Cartilage. 2018 ; Vol. 26, No. 11. pp. 1562-1569.
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abstract = "Objective: Magnetic resonance imaging (MRI)-detected structural features are associated with increased risk of radiographic osteoarthritis (ROA). Specific mitochondrial DNA (mtDNA) haplogroups have been associated with incident ROA. Our objective was to compare the presence of MRI-detected structural features across mtDNA haplogroups among knees that developed incident ROA. Design: Knees from the Osteoarthritis Initiative (OAI) that developed incident ROA during 48 months follow-up were identified from Caucasian participants. mtDNA haplogroups were assigned based on a single base extension assay. MRIs were obtained annually between baseline and 4-year follow-up and scored using the MRI Osteoarthritis Knee Score (MOAKS). The association between mtDNA haplogroups and MRI-detected structural features was estimated using log-binomial regression. Participants who carried haplogroup H served as the reference group. Results: The sample included 255 participants contributing 277 knees that developed ROA. Haplogroups included H (116, 45{\%}), J (17, 7{\%}), T (26, 10{\%}), Uk (61, 24{\%}), and the remaining less common haplogroups (“others”) (35, 14{\%}). Knees of participants with haplogroup J had significantly lower risk of medium/large bone marrow lesions (BMLs) in the medial compartment [3.2{\%}, relative risks (RR) = 0.17; 95{\%}CI: 0.05, 0.64; P = 0.009] compared to knees of participants who carried haplogroup H [16.3{\%}], as did knees from participants within the “others” group [2.8{\%}, RR = 0.20; 95{\%}CI: 0.08, 0.55; P = 0.002], over the 4 year follow-up period. Conclusions: mtDNA haplogroup J was associated with lower risk of BMLs in the medial compartment among knees that developed ROA. Our results offer a potential hypothesis to explain the mechanism underlying the previously reported protective association between haplogroup J and ROA.",
keywords = "Bone marrow lesions, Haplogroups, Knee osteoarthritis, Meniscus, Mitochondrial DNA, MRI",
author = "I. Rego-P{\'e}rez and Blanco, {F. J.} and Roemer, {F. W.} and A. Guermazi and D. Ran and Ashbeck, {E. L.} and M. Fern{\'a}ndez-Moreno and N. Oreiro and Hannon, {M. J.} and Hunter, {D. J.} and Kwoh, {Chian K}",
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AU - Rego-Pérez, I.

AU - Blanco, F. J.

AU - Roemer, F. W.

AU - Guermazi, A.

AU - Ran, D.

AU - Ashbeck, E. L.

AU - Fernández-Moreno, M.

AU - Oreiro, N.

AU - Hannon, M. J.

AU - Hunter, D. J.

AU - Kwoh, Chian K

PY - 2018/11/1

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N2 - Objective: Magnetic resonance imaging (MRI)-detected structural features are associated with increased risk of radiographic osteoarthritis (ROA). Specific mitochondrial DNA (mtDNA) haplogroups have been associated with incident ROA. Our objective was to compare the presence of MRI-detected structural features across mtDNA haplogroups among knees that developed incident ROA. Design: Knees from the Osteoarthritis Initiative (OAI) that developed incident ROA during 48 months follow-up were identified from Caucasian participants. mtDNA haplogroups were assigned based on a single base extension assay. MRIs were obtained annually between baseline and 4-year follow-up and scored using the MRI Osteoarthritis Knee Score (MOAKS). The association between mtDNA haplogroups and MRI-detected structural features was estimated using log-binomial regression. Participants who carried haplogroup H served as the reference group. Results: The sample included 255 participants contributing 277 knees that developed ROA. Haplogroups included H (116, 45%), J (17, 7%), T (26, 10%), Uk (61, 24%), and the remaining less common haplogroups (“others”) (35, 14%). Knees of participants with haplogroup J had significantly lower risk of medium/large bone marrow lesions (BMLs) in the medial compartment [3.2%, relative risks (RR) = 0.17; 95%CI: 0.05, 0.64; P = 0.009] compared to knees of participants who carried haplogroup H [16.3%], as did knees from participants within the “others” group [2.8%, RR = 0.20; 95%CI: 0.08, 0.55; P = 0.002], over the 4 year follow-up period. Conclusions: mtDNA haplogroup J was associated with lower risk of BMLs in the medial compartment among knees that developed ROA. Our results offer a potential hypothesis to explain the mechanism underlying the previously reported protective association between haplogroup J and ROA.

AB - Objective: Magnetic resonance imaging (MRI)-detected structural features are associated with increased risk of radiographic osteoarthritis (ROA). Specific mitochondrial DNA (mtDNA) haplogroups have been associated with incident ROA. Our objective was to compare the presence of MRI-detected structural features across mtDNA haplogroups among knees that developed incident ROA. Design: Knees from the Osteoarthritis Initiative (OAI) that developed incident ROA during 48 months follow-up were identified from Caucasian participants. mtDNA haplogroups were assigned based on a single base extension assay. MRIs were obtained annually between baseline and 4-year follow-up and scored using the MRI Osteoarthritis Knee Score (MOAKS). The association between mtDNA haplogroups and MRI-detected structural features was estimated using log-binomial regression. Participants who carried haplogroup H served as the reference group. Results: The sample included 255 participants contributing 277 knees that developed ROA. Haplogroups included H (116, 45%), J (17, 7%), T (26, 10%), Uk (61, 24%), and the remaining less common haplogroups (“others”) (35, 14%). Knees of participants with haplogroup J had significantly lower risk of medium/large bone marrow lesions (BMLs) in the medial compartment [3.2%, relative risks (RR) = 0.17; 95%CI: 0.05, 0.64; P = 0.009] compared to knees of participants who carried haplogroup H [16.3%], as did knees from participants within the “others” group [2.8%, RR = 0.20; 95%CI: 0.08, 0.55; P = 0.002], over the 4 year follow-up period. Conclusions: mtDNA haplogroup J was associated with lower risk of BMLs in the medial compartment among knees that developed ROA. Our results offer a potential hypothesis to explain the mechanism underlying the previously reported protective association between haplogroup J and ROA.

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