Mitochondrial fatty acid synthesis type II: More than just fatty acids

J. Kalervo Hiltunen, Melissa S. Schonauer, Kaija J. Autio, Telsa M. Mittelmeier, Alexander J. Kastaniotis, Carol L Dieckmann

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Eukaryotes harbor a highly conserved mitochondrial pathway for fatty acid synthesis (FAS), which is completely independent of the eukaryotic cytosolic FAS apparatus. The activities of the mitochondrial FAS system are catalyzed by soluble enzymes, and the pathway thus resembles its prokaryotic counterparts. Except for octanoic acid,whichis the direct precursor for lipoic acid synthesis, other end products and functions of the mitochondrial FAS pathway are still largely enigmatic. In addition to low cellular levels of lipoic acid, disruption of genes encoding mitochondrial FAS enzymes in yeast results in a respiratory-deficient phenotype and small rudimentary mitochondria. Recently, two distinct links between mitochondrial FAS and RNA processing have been discovered in vertebrates and yeast, respectively. In vertebrates, the mitochondrial 3-hydroxyacyl-acyl carrier protein dehydratase and the RPP14 subunit of RNase P are encoded by the same bicistronic transcript in an evolutionarily conserved arrangement that is unusual for eukaryotes. In yeast, defects in mitochondrial FAS result in inefficient RNase P cleavage in the organelle. The intersection of mitochondrial FAS and RNA metabolism in both systems provides a novel mechanism for the coordination of intermediary metabolism in eukaryotic cells.

Original languageEnglish (US)
Pages (from-to)9011-9015
Number of pages5
JournalJournal of Biological Chemistry
Volume284
Issue number14
DOIs
StatePublished - Apr 3 2009

Fingerprint

Fatty Acids
Ribonuclease P
Thioctic Acid
Yeast
Yeasts
Eukaryota
Vertebrates
Metabolism
RNA
Mitochondrial Genes
Mitochondria
Eukaryotic Cells
Gene encoding
Enzymes
Organelles
Ports and harbors
Thermodynamic properties
Phenotype
Defects
Processing

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Hiltunen, J. K., Schonauer, M. S., Autio, K. J., Mittelmeier, T. M., Kastaniotis, A. J., & Dieckmann, C. L. (2009). Mitochondrial fatty acid synthesis type II: More than just fatty acids. Journal of Biological Chemistry, 284(14), 9011-9015. https://doi.org/10.1074/jbc.R800068200

Mitochondrial fatty acid synthesis type II : More than just fatty acids. / Hiltunen, J. Kalervo; Schonauer, Melissa S.; Autio, Kaija J.; Mittelmeier, Telsa M.; Kastaniotis, Alexander J.; Dieckmann, Carol L.

In: Journal of Biological Chemistry, Vol. 284, No. 14, 03.04.2009, p. 9011-9015.

Research output: Contribution to journalArticle

Hiltunen, JK, Schonauer, MS, Autio, KJ, Mittelmeier, TM, Kastaniotis, AJ & Dieckmann, CL 2009, 'Mitochondrial fatty acid synthesis type II: More than just fatty acids', Journal of Biological Chemistry, vol. 284, no. 14, pp. 9011-9015. https://doi.org/10.1074/jbc.R800068200
Hiltunen JK, Schonauer MS, Autio KJ, Mittelmeier TM, Kastaniotis AJ, Dieckmann CL. Mitochondrial fatty acid synthesis type II: More than just fatty acids. Journal of Biological Chemistry. 2009 Apr 3;284(14):9011-9015. https://doi.org/10.1074/jbc.R800068200
Hiltunen, J. Kalervo ; Schonauer, Melissa S. ; Autio, Kaija J. ; Mittelmeier, Telsa M. ; Kastaniotis, Alexander J. ; Dieckmann, Carol L. / Mitochondrial fatty acid synthesis type II : More than just fatty acids. In: Journal of Biological Chemistry. 2009 ; Vol. 284, No. 14. pp. 9011-9015.
@article{c95736019052421f92f1655cf615155f,
title = "Mitochondrial fatty acid synthesis type II: More than just fatty acids",
abstract = "Eukaryotes harbor a highly conserved mitochondrial pathway for fatty acid synthesis (FAS), which is completely independent of the eukaryotic cytosolic FAS apparatus. The activities of the mitochondrial FAS system are catalyzed by soluble enzymes, and the pathway thus resembles its prokaryotic counterparts. Except for octanoic acid,whichis the direct precursor for lipoic acid synthesis, other end products and functions of the mitochondrial FAS pathway are still largely enigmatic. In addition to low cellular levels of lipoic acid, disruption of genes encoding mitochondrial FAS enzymes in yeast results in a respiratory-deficient phenotype and small rudimentary mitochondria. Recently, two distinct links between mitochondrial FAS and RNA processing have been discovered in vertebrates and yeast, respectively. In vertebrates, the mitochondrial 3-hydroxyacyl-acyl carrier protein dehydratase and the RPP14 subunit of RNase P are encoded by the same bicistronic transcript in an evolutionarily conserved arrangement that is unusual for eukaryotes. In yeast, defects in mitochondrial FAS result in inefficient RNase P cleavage in the organelle. The intersection of mitochondrial FAS and RNA metabolism in both systems provides a novel mechanism for the coordination of intermediary metabolism in eukaryotic cells.",
author = "Hiltunen, {J. Kalervo} and Schonauer, {Melissa S.} and Autio, {Kaija J.} and Mittelmeier, {Telsa M.} and Kastaniotis, {Alexander J.} and Dieckmann, {Carol L}",
year = "2009",
month = "4",
day = "3",
doi = "10.1074/jbc.R800068200",
language = "English (US)",
volume = "284",
pages = "9011--9015",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "14",

}

TY - JOUR

T1 - Mitochondrial fatty acid synthesis type II

T2 - More than just fatty acids

AU - Hiltunen, J. Kalervo

AU - Schonauer, Melissa S.

AU - Autio, Kaija J.

AU - Mittelmeier, Telsa M.

AU - Kastaniotis, Alexander J.

AU - Dieckmann, Carol L

PY - 2009/4/3

Y1 - 2009/4/3

N2 - Eukaryotes harbor a highly conserved mitochondrial pathway for fatty acid synthesis (FAS), which is completely independent of the eukaryotic cytosolic FAS apparatus. The activities of the mitochondrial FAS system are catalyzed by soluble enzymes, and the pathway thus resembles its prokaryotic counterparts. Except for octanoic acid,whichis the direct precursor for lipoic acid synthesis, other end products and functions of the mitochondrial FAS pathway are still largely enigmatic. In addition to low cellular levels of lipoic acid, disruption of genes encoding mitochondrial FAS enzymes in yeast results in a respiratory-deficient phenotype and small rudimentary mitochondria. Recently, two distinct links between mitochondrial FAS and RNA processing have been discovered in vertebrates and yeast, respectively. In vertebrates, the mitochondrial 3-hydroxyacyl-acyl carrier protein dehydratase and the RPP14 subunit of RNase P are encoded by the same bicistronic transcript in an evolutionarily conserved arrangement that is unusual for eukaryotes. In yeast, defects in mitochondrial FAS result in inefficient RNase P cleavage in the organelle. The intersection of mitochondrial FAS and RNA metabolism in both systems provides a novel mechanism for the coordination of intermediary metabolism in eukaryotic cells.

AB - Eukaryotes harbor a highly conserved mitochondrial pathway for fatty acid synthesis (FAS), which is completely independent of the eukaryotic cytosolic FAS apparatus. The activities of the mitochondrial FAS system are catalyzed by soluble enzymes, and the pathway thus resembles its prokaryotic counterparts. Except for octanoic acid,whichis the direct precursor for lipoic acid synthesis, other end products and functions of the mitochondrial FAS pathway are still largely enigmatic. In addition to low cellular levels of lipoic acid, disruption of genes encoding mitochondrial FAS enzymes in yeast results in a respiratory-deficient phenotype and small rudimentary mitochondria. Recently, two distinct links between mitochondrial FAS and RNA processing have been discovered in vertebrates and yeast, respectively. In vertebrates, the mitochondrial 3-hydroxyacyl-acyl carrier protein dehydratase and the RPP14 subunit of RNase P are encoded by the same bicistronic transcript in an evolutionarily conserved arrangement that is unusual for eukaryotes. In yeast, defects in mitochondrial FAS result in inefficient RNase P cleavage in the organelle. The intersection of mitochondrial FAS and RNA metabolism in both systems provides a novel mechanism for the coordination of intermediary metabolism in eukaryotic cells.

UR - http://www.scopus.com/inward/record.url?scp=66149091123&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66149091123&partnerID=8YFLogxK

U2 - 10.1074/jbc.R800068200

DO - 10.1074/jbc.R800068200

M3 - Article

C2 - 19028688

AN - SCOPUS:66149091123

VL - 284

SP - 9011

EP - 9015

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 14

ER -