Mitochondrial genomics and proteomics

Melissa S. Schonauer, Carol L. Dieckmann

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Factors involved in mitochondrial biogenesis and function have been studied classically via mutagenesis screens and subsequent genetic and biochemical analyses. The recent advent of high-throughput technologies has provided a wealth of information regarding mitochondrial function, morphology, gene regulation, protein complexes, and disease in a fraction of the time. This review will describe past and present genomic and proteomic methods used to study mitochondria both in yeast and mammalian cells, their advantages and limitations, and the current knowledge of the number of genes and proteins that are required for proper functioning of the organelle.

Original languageEnglish (US)
Pages (from-to)575-588
Number of pages14
JournalCurrent Genomics
Volume5
Issue number7
DOIs
StatePublished - Nov 1 2004

Keywords

  • Diauxic shift
  • Mitochondrial biogenesis
  • Organelle
  • Respiration
  • Saccharomyces

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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