Mitochondrial Ion channels in metabolic disease

Aaron H. Truong, Saravanakumar Murugesan, Katia D. Youssef, Ayako Makino

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Mitochondria are small organelles that reside in most eukaryotic cells and are responsible for cellular energy production. They are also involved in other cellular signaling pathways including cell apoptosis. Mitochondria are composed of two phospholipid bilayers: the outer mitochondrial membrane and the inner mitochondrial membrane; and two aqueous spaces: the intermembrane space and the matrix. Like the plasma membrane, many ion channels are located in the mitochondrial membranes and play a critical role in mitochondrial functions. Increasing evidence suggests that the dysregulation of mitochondrial ion channels is implicated in the development and progression of cardiovascular diseases. In this chapter, we review the role of mitochondrial ion channels in metabolic disease.

Original languageEnglish (US)
Title of host publicationVascular Ion Channels in Physiology and Disease
PublisherSpringer International Publishing
Number of pages23
ISBN (Electronic)9783319296357
ISBN (Print)9783319296333
StatePublished - Jan 1 2016


  • Cardiovascular disease
  • Cell apoptosis
  • Coronary arterial disease
  • Mitochondrial calcium overload
  • VDAC

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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