Abstract
Mitochondria are small organelles that reside in most eukaryotic cells and are responsible for cellular energy production. They are also involved in other cellular signaling pathways including cell apoptosis. Mitochondria are composed of two phospholipid bilayers: the outer mitochondrial membrane and the inner mitochondrial membrane; and two aqueous spaces: the intermembrane space and the matrix. Like the plasma membrane, many ion channels are located in the mitochondrial membranes and play a critical role in mitochondrial functions. Increasing evidence suggests that the dysregulation of mitochondrial ion channels is implicated in the development and progression of cardiovascular diseases. In this chapter, we review the role of mitochondrial ion channels in metabolic disease.
| Original language | English (US) |
|---|---|
| Title of host publication | Vascular Ion Channels in Physiology and Disease |
| Publisher | Springer International Publishing |
| Pages | 397-419 |
| Number of pages | 23 |
| ISBN (Electronic) | 9783319296357 |
| ISBN (Print) | 9783319296333 |
| DOIs | |
| State | Published - Jan 1 2016 |
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Keywords
- Cardiovascular disease
- Cell apoptosis
- Coronary arterial disease
- Mitochondrial calcium overload
- VDAC
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Mitochondrial Ion channels in metabolic disease. / Truong, Aaron H.; Murugesan, Saravanakumar; Youssef, Katia D.; Makino, Ayako.
Vascular Ion Channels in Physiology and Disease. Springer International Publishing, 2016. p. 397-419.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Mitochondrial Ion channels in metabolic disease
AU - Truong, Aaron H.
AU - Murugesan, Saravanakumar
AU - Youssef, Katia D.
AU - Makino, Ayako
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Mitochondria are small organelles that reside in most eukaryotic cells and are responsible for cellular energy production. They are also involved in other cellular signaling pathways including cell apoptosis. Mitochondria are composed of two phospholipid bilayers: the outer mitochondrial membrane and the inner mitochondrial membrane; and two aqueous spaces: the intermembrane space and the matrix. Like the plasma membrane, many ion channels are located in the mitochondrial membranes and play a critical role in mitochondrial functions. Increasing evidence suggests that the dysregulation of mitochondrial ion channels is implicated in the development and progression of cardiovascular diseases. In this chapter, we review the role of mitochondrial ion channels in metabolic disease.
AB - Mitochondria are small organelles that reside in most eukaryotic cells and are responsible for cellular energy production. They are also involved in other cellular signaling pathways including cell apoptosis. Mitochondria are composed of two phospholipid bilayers: the outer mitochondrial membrane and the inner mitochondrial membrane; and two aqueous spaces: the intermembrane space and the matrix. Like the plasma membrane, many ion channels are located in the mitochondrial membranes and play a critical role in mitochondrial functions. Increasing evidence suggests that the dysregulation of mitochondrial ion channels is implicated in the development and progression of cardiovascular diseases. In this chapter, we review the role of mitochondrial ion channels in metabolic disease.
KW - Cardiovascular disease
KW - Cell apoptosis
KW - Coronary arterial disease
KW - Mitochondrial calcium overload
KW - VDAC
UR - http://www.scopus.com/inward/record.url?scp=85017626339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017626339&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-29635-7_18
DO - 10.1007/978-3-319-29635-7_18
M3 - Chapter
SN - 9783319296333
SP - 397
EP - 419
BT - Vascular Ion Channels in Physiology and Disease
PB - Springer International Publishing
ER -