Mitochondrial Ion channels in metabolic disease

Aaron H. Truong; Saravanakumar Murugesan; Katia D. Youssef; Ayako Makino

doi:10.1007/978-3-319-29635-7_18

Mitochondrial Ion channels in metabolic disease

Aaron H. Truong, Saravanakumar Murugesan, Katia D. Youssef, Ayako Makino

Physiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

6 Scopus citations

Abstract

Mitochondria are small organelles that reside in most eukaryotic cells and are responsible for cellular energy production. They are also involved in other cellular signaling pathways including cell apoptosis. Mitochondria are composed of two phospholipid bilayers: the outer mitochondrial membrane and the inner mitochondrial membrane; and two aqueous spaces: the intermembrane space and the matrix. Like the plasma membrane, many ion channels are located in the mitochondrial membranes and play a critical role in mitochondrial functions. Increasing evidence suggests that the dysregulation of mitochondrial ion channels is implicated in the development and progression of cardiovascular diseases. In this chapter, we review the role of mitochondrial ion channels in metabolic disease.

Original language	English (US)
Title of host publication	Vascular Ion Channels in Physiology and Disease
Publisher	Springer International Publishing
Pages	397-419
Number of pages	23
ISBN (Electronic)	9783319296357
ISBN (Print)	9783319296333
DOIs	https://doi.org/10.1007/978-3-319-29635-7_18
State	Published - Jan 1 2016

Keywords

Cardiovascular disease
Cell apoptosis
Coronary arterial disease
Mitochondrial calcium overload
VDAC

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Mitochondria are small organelles that reside in most eukaryotic cells and are responsible for cellular energy production. They are also involved in other cellular signaling pathways including cell apoptosis. Mitochondria are composed of two phospholipid bilayers: the outer mitochondrial membrane and the inner mitochondrial membrane; and two aqueous spaces: the intermembrane space and the matrix. Like the plasma membrane, many ion channels are located in the mitochondrial membranes and play a critical role in mitochondrial functions. Increasing evidence suggests that the dysregulation of mitochondrial ion channels is implicated in the development and progression of cardiovascular diseases. In this chapter, we review the role of mitochondrial ion channels in metabolic disease.",

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AU - Murugesan, Saravanakumar

AU - Youssef, Katia D.

AU - Makino, Ayako

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AB - Mitochondria are small organelles that reside in most eukaryotic cells and are responsible for cellular energy production. They are also involved in other cellular signaling pathways including cell apoptosis. Mitochondria are composed of two phospholipid bilayers: the outer mitochondrial membrane and the inner mitochondrial membrane; and two aqueous spaces: the intermembrane space and the matrix. Like the plasma membrane, many ion channels are located in the mitochondrial membranes and play a critical role in mitochondrial functions. Increasing evidence suggests that the dysregulation of mitochondrial ion channels is implicated in the development and progression of cardiovascular diseases. In this chapter, we review the role of mitochondrial ion channels in metabolic disease.

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KW - Mitochondrial calcium overload

KW - VDAC

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