Mitochondrial Miro GTPases coordinate mitochondrial and peroxisomal dynamics

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Mitochondria and peroxisomes are highly dynamic, multifunctional organelles. Both perform key roles for cellular physiology and homoeostasis by mediating bioenergetics, biosynthesis, and/or signalling. To support cellular function, they must be properly distributed, of proper size, and be able to interact with other organelles. Accumulating evidence suggests that the small atypical GTPase Miro provides a central signalling node to coordinate mitochondrial as well as peroxisomal dynamics. In this review, I summarize our current understanding of Miro-dependent functions and molecular mechanisms underlying the proper distribution, size and function of mitochondria and peroxisomes.

Original languageEnglish (US)
Pages (from-to)372-398
Number of pages27
JournalSmall GTPases
Volume12
Issue number5-6
DOIs
StatePublished - 2021

Keywords

  • Miro
  • Small GTPase
  • membrane dynamics
  • mitochondria
  • mitochondrial dynamics
  • motility
  • peroxisomal dynamics
  • peroxisome

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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