Mitochondrial transport dynamics in axons and dendrites

Konrad E. Zinsmaier, Milos Babic, Gary J. Russo

Research output: Chapter in Book/Report/Conference proceedingChapter

30 Scopus citations

Abstract

Mitochondrial dynamics and transport have emerged as key factors in the regulation of neuronal differentiation and survival. Mitochondria are dynamically transported in and out of axons and dendrites to maintain neuronal and synaptic function. Transport proceeds through a controlled series of plus- and minus-end directed movements along microtubule tracks (MTs) that are often interrupted by short stops. This bidirectional motility of mitochondria is facilitated by plus end-directed kinesin and minus end-directed dynein motors, and may be coordinated and controlled by a number of mechanisms that integrate intracellular signals to ensure efficient transport and targeting of mitochondria. In this chapter, we discuss our understanding of mechanisms that facilitate mitochondrial transport and delivery to specific target sites in dendrites and axons.

Original languageEnglish (US)
Title of host publicationCell Biology of the Axon
EditorsEdward Koenig
Pages107-139
Number of pages33
DOIs
StatePublished - Sep 21 2009

Publication series

NameResults and Problems in Cell Differentiation
Volume48
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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