Mitomycin C toxicity and pharmacokinetics in mice given sulfur nucleophiles

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Abstract

The sulfur nucleophiles, sodium thiosulfate (Na2S2O3) and N-acetylcysteine (NAC) given in maximally tolerated doses did not reduce the hematological toxicity of high dose mitomycin C (MMC) in normal mice. In addition, neither sulfur nucleophile significantly altered the antileukemic activity of MMC. Pharmacokinetic studies of MMC in normal mice, demonstrated rapid plasma elimination (T1/2β = 0.53 hrs) and substantial drug distribution to the bone marrow which was enhanced by NAC. These results demonstrate a lack of MMC antidotal activity for Na2S2O3 and NAC.

Original languageEnglish (US)
Pages (from-to)733-738
Number of pages6
JournalAnticancer Research
Volume8
Issue number4
Publication statusPublished - 1988

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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